Results 51 to 60 of about 30,157 (159)

Alpers disease mutations in human mitochondrial DNA polymerase cause catalytic defects in mitochondrial DNA replication by distinct mechanisms

Frontiers in Genetics, 2015
The human mitochondrial DNA polymerase gamma (Pol-γ) is nuclearly encoded and is responsible for the replication and repair of the mitochondrial genome. Mutations S305R and P1073L in the POLG gene have been reported to be associated with early-childhood ...
Yufeng eQian, Jessica eZiehr, Kenneth eJohnson   +2 more
doaj   +1 more source

Bipolar Androgen Therapy as a Potential Mechanistic Bridge to Enhance PARP Inhibitor Efficacy in Prostate Cancer

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Prostate cancer remains a leading cause of cancer‐related mortality, largely driven by progression to metastatic castration‐resistant prostate cancer (mCRPC). Although poly(ADP‐ribose) polymerase inhibitors (PARPis) have improved outcomes in patients with homologous recombination repair (HRR) alterations, particularly in BRCA2‐mutated disease,
Jhen‐Hao Jhan, Jiun‐Hung Geng, Hung‐Lung Ke, Shu‐Pin Huang, Li Jia   +4 more
wiley   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

Ufd1-Npl4 Recruit Cdc48 for Disassembly of Ubiquitylated CMG Helicase at the End of Chromosome Replication

Cell Reports, 2017
Disassembly of the Cdc45-MCM-GINS (CMG) DNA helicase is the key regulated step during DNA replication termination in eukaryotes, involving ubiquitylation of the Mcm7 helicase subunit, leading to a disassembly process that requires the Cdc48 “segregase ...
Marija Maric, Progya Mukherjee, Michael H. Tatham, Ronald Hay, Karim Labib   +4 more
doaj   +1 more source

Kinetic Control of Condensate Function: How the Formation Dynamics of APBs Influence ALT Cancer Telomere Length Heterogeneity

BioEssays, Volume 48, Issue 10, October 2026.
The dynamics of PML body formation at telomeres in cancer cells using the alternative lengthening of telomeres (ALT) pathway for telomere elongation correlate with different degrees of ALT activity and might contribute to telomere length heterogeneity in ALT cancer cells.
Huaiying Zhang
wiley   +1 more source

Noncoding RNA Transcripts Based Molecular Phenotyping of MASLD and MASH Patients

Liver International Communications, Volume 7, Issue 3, September 2026.
ABSTRACT Background and Aims Metabolic dysfunction‐associated steatotic liver disease (MASLD) is a progressive hepatic metabolic disorder characterized by excessive fat accumulation in hepatocytes. MASLD can advance to metabolic dysfunction‐associated steatohepatitis (MASH).
Frida M. Delgadillo, Karla Perez, Barbara Yang, Subramanian Dhandayuthapani, Murali M. Yallapu, Subhash C. Chauhan, Enrique I. Ramos, Shrikanth S. Gadad   +7 more
wiley   +1 more source

Structural and biophysical characterization of Mycobacterium tuberculosis DciA reveals functional convergence in DnaB helicase recognition

Protein Science, Volume 35, Issue 9, September 2026.
Abstract In bacteria, DnaB replicative helicases are essential for unwinding genomic DNA to provide the single‐stranded templates required for replication. The recruitment of the hexameric DnaB helicase to the origin of replication is mediated by distinct mechanisms that rely on specialized factors known as helicase loaders. The DciA family of helicase
Daniele Mazzoletti, Andrea Garavaglia, Hayden Fisher, Nicholas Gao, Castrese Morrone, Paul Dominic B. Olinares, Brian T. Chait, David Jeruzalmi, Riccardo Miggiano   +8 more
wiley   +1 more source

Accelerated Adaptive Evolution of Gram‐Negative Bacteria With a Broad‐Host‐Range Dual Base Editor

Microbial Biotechnology, Volume 19, Issue 9, September 2026.
We developed a broad‐host‐range dual base editor that transiently induces genome‐wide hypermutation, accelerating adaptive laboratory evolution by up to four orders of magnitude. The platform rapidly generates improved bacterial phenotypes across diverse Gram‐negative species, enabling faster evolutionary engineering for biotechnology.
Tomas Aparicio, Gabriele Capriglia, Francesca Mapelli, Sara Borin, Víctor de Lorenzo   +4 more
wiley   +1 more source

The p97 segregase cofactor Ubxn7 facilitates replisome disassembly during S-phase [PDF]

, 2022
Complex cellular processes are driven by the regulated assembly and disassembly of large multiprotein complexes. While we are beginning to understand the molecular mechanism for assembly of the eukaryotic DNA replication machinery (replisome), we still ...
Tarcan, Zeynep, Gambus, Agnieszka; id_orcid, Divyasree Poovathumkadavil, Gambus, Agnieszka, Poovathumkadavil, Divyasree, Zeynep Tarcan, Aggeliki Skagia, Skagia, Aggeliki, Agnieszka Gambus   +8 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, Volume 20, Issue 8, Page 2054-2084, August 2026.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source