Results 41 to 50 of about 30,157 (159)
Supporting data for “Structural and Functional Characterization of the Eukaryotic Replisome”
, 2023 The dataset provided is associated with the doctoral thesis titled "Structural and Functional Characterization of the Eukaryotic Replisome". This comprehensive dataset encompasses various experimental techniques and methodologies employed to investigate ...
Zhichun Xu (9069383)
core +1 more source
The Interplay of Cohesin and the Replisome at Processive and Stressed DNA Replication Forks
Cells, 2021 The cohesin complex facilitates faithful chromosome segregation by pairing the sister chromatids after DNA replication until mitosis. In addition, cohesin contributes to proficient and error-free DNA replication.
Janne J. M. van Schie, Job de Lange
doaj +1 more source
Degradation of replisome components prevents genomic instability.
, 2013 Models for the roles of the FPC in replisome stabilization. The FPC (Swi1-Swi3) stabilizes the replication fork (left; FPC+) and replisome components and promotes an efficient progression of the replication fork.
Chiaki Noguchi (102477) +5 more
core +1 more source
Coordinated DNA Replication by the Bacteriophage T4 Replisome
Viruses, 2015 The T4 bacteriophage encodes eight proteins, which are sufficient to carry out coordinated leading and lagging strand DNA synthesis. These purified proteins have been used to reconstitute DNA synthesis in vitro and are a well-characterized model system ...
Erin Noble +2 more
doaj +1 more source
Unraveling G‐Quadruplex and i‐Motif Coexistence Within a Double‐Stranded DNA
Angewandte Chemie, Volume 138, Issue 31, 27 July 2026.The relative thermodynamic profiles of G‐quadruplex (G4), i‐Motif (iM), and the duplex counterpart tune the simultaneous G4 and iM formation within a double‐stranded (ds) DNA. ABSTRACT DNA can transiently fold into variable arrangements, which are expected to exploit regulatory functions. Guanine‐rich sequences can fold into G‐quadruplexes (G4s), while
Davide Auricchio +7 more
wiley +2 more sources
Direct visualization of translesion DNA synthesis polymerase IV at the replisome [PDF]
, 2022 In bacterial cells, DNA damage tolerance is manifested by the action of translesion DNA polymerases that can synthesize DNA across template lesions that typically block the replicative DNA polymerase III.
Kowalczykowski, Stephen C +6 more
core +1 more source
Antibiotics, 2018 DNA replication is an essential process. Although the fundamental strategies to duplicate chromosomes are similar in all free-living organisms, the enzymes of the three domains of life that perform similar functions in DNA replication differ in amino ...
Jon M. Kaguni
doaj +1 more source
Advanced Science, EarlyView.This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu +5 more
wiley +1 more source
A Cytosine‑Bulged (3+1) Hybrid G‑Quadruplex Formed by the Chicken DNA Replication Origin
Chemistry – A European Journal, EarlyView.The first high‐resolution structure of an OGRE‐derived G‐quadruplex from the chicken β‐globin replication origin reveals an intramolecular three‐layer (3+1) hybrid fold with a cytosine bulge and an unprecedented 5'‐outer‐quartet anti guanine, creating a distinctive surface for molecular recognition.
Yingying You +13 more
wiley +1 more source
Mitotic replisome disassembly in vertebrates
, 2018 Recent years have brought a breakthrough in our understanding of the process of eukaryotic DNA replication termination. We have shown that the process of replication machinery (replisome) disassembly at the termination of DNA replication forks in S-phase
Gambus, Agnieszka; id_orcid +3 more
core +1 more source