Results 21 to 30 of about 30,157 (159)
Biology, 2021 Cohesion between replicated chromosomes is essential for chromatin dynamics and equal segregation of duplicated genetic material. In the G1 phase, the ring-shaped cohesin complex is loaded onto duplex DNA, enriching at replication start sites, or ...
Sarah S. Henrikus, Alessandro Costa
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Localization of an accessory helicase at the replisome is critical in sustaining efficient genome duplication [PDF]
, 2010 © The Author(s) 2010. Published by Oxford University PressGenome duplication requires accessory helicases to displace proteins ahead of advancing replication forks.
Lloyd, RG +11 more
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Speed variations of bacterial replisomes
eLife, 2022 Replisomes are multi-protein complexes that replicate genomes with remarkable speed and accuracy. Despite their importance, their dynamics is poorly characterized, especially in vivo.
Deepak Bhat +4 more
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Sen1 Is Recruited to Replication Forks via Ctf4 and Mrc1 and Promotes Genome Stability
Cell Reports, 2020 Summary: DNA replication and RNA transcription compete for the same substrate during S phase. Cells have evolved several mechanisms to minimize such conflicts.
Rowin Appanah +4 more
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Cell Reports, 2019 Summary: Disassembly of the replisome is the final step of chromosome duplication in eukaryotes. In budding yeast and metazoa, cullin ubiquitin ligases are required to ubiquitylate the Cdc45-MCM-GINS (CMG) helicase that lies at the heart of the replisome,
Progya P. Mukherjee, Karim P.M. Labib
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Single-Molecule Studies of the Replisome [PDF]
, 2010 Replication of DNA is carried out by the replisome, a multiprotein complex responsible for the unwinding of parental DNA and the synthesis of DNA on each of the two DNA strands.
Loparo, Joseph J., +3 more
core +2 more sources
Transcription leads to pervasive replisome instability in bacteria
eLife, 2017 The canonical model of DNA replication describes a highly-processive and largely continuous process by which the genome is duplicated. This continuous model is based upon in vitro reconstitution and in vivo ensemble experiments. Here, we characterize the
Sarah M Mangiameli +3 more
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eLife, 2021 Clamp loaders are AAA+ ATPases that load sliding clamps onto DNA. We mapped the mutational sensitivity of the T4 bacteriophage sliding clamp and clamp loader by deep mutagenesis, and found that residues not involved in catalysis or binding display ...
Subu Subramanian +7 more
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The Response of the Replication Apparatus to Leading Template Strand Blocks
Cells, 2023 Duplication of the genome requires the replication apparatus to overcome a variety of impediments, including covalent DNA adducts, the most challenging of which is on the leading template strand.
Marina A. Bellani +4 more
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The human CTF4-orthologue AND-1 interacts with DNA polymerase α/primase via its unique C-terminal HMG box [PDF]
Open Biology, 2017 A dynamic multi-protein assembly known as the replisome is responsible for DNA synthesis in eukaryotic cells. In yeast, the hub protein Ctf4 bridges DNA helicase and DNA polymerase and recruits factors with roles in metabolic processes coupled to DNA ...
Mairi L. Kilkenny +5 more
doaj +1 more source