Results 11 to 20 of about 30,157 (159)
The DNA-Binding Domain of S. pombe Mrc1 (Claspin) Acts to Enhance Stalling at Replication Barriers. [PDF]
PLoS ONE, 2015 During S-phase replication forks can stall at specific genetic loci. At some loci, the stalling events depend on the replisome components Schizosaccharomyces pombe Swi1 (Saccharomyces cerevisiae Tof1) and Swi3 (S. cerevisiae Csm3) as well as factors that
Juergen Zech +4 more
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Characterizing replisome disassembly in human cells [PDF]
iScienceSummary: To ensure timely duplication of the entire eukaryotic genome, thousands of replication machineries (replisomes) act on genomic DNA at any time during S phase. In the final stages of this process, replisomes are unloaded from chromatin. Unloading
Rebecca M. Jones +10 more
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Roles of the mitochondrial replisome in mitochondrial DNA deletion formation [PDF]
Genetics and Molecular Biology, 2020 Mitochondrial DNA (mtDNA) deletions are a common cause of human mitochondrial diseases. Mutations in the genes encoding components of the mitochondrial replisome, such as DNA polymerase gamma (Pol γ) and the mtDNA helicase Twinkle, have been associated ...
Marcos T. Oliveira +2 more
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Chromosome organization shapes replisome dynamics in Caulobacter crescentus
Nature CommunicationsDNA replication in bacteria takes place on highly compacted chromosomes, where segregation, transcription, and repair must occur simultaneously. Within this dynamic environment, colocalization of sister replisomes has been observed in many bacterial ...
Chen Zhang +5 more
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USP37 prevents unscheduled replisome unloading through MCM complex deubiquitination
Nature CommunicationsThe CMG helicase (CDC45-MCM2-7-GINS) unwinds DNA as a component of eukaryotic replisomes. Replisome (dis)assembly is tightly coordinated with cell cycle progression to ensure genome stability.
Derek L. Bolhuis +7 more
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Fragment-based interrogation of a bacterial replisome [PDF]
, 2020 Chromosomes are replicated by the replisome, a molecular machine comprised of a set of interacting proteins with interdependent functions. In previous work, a fragment library was screened in vitro against a bacterial replisome, reconstituted from ...
Lamoree, Bas
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Elucidation and characterisation of checkpoint kinase interactions with the replisome [PDF]
, 2023 DNA must be accurately and faithfully copied in each cell cycle by the process of DNA replication. During replication, cells must endure assaults from a myriad of exogenous and endogenous agents and events which can interfere with replication. Cells have
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Replisome passage through the cohesin ring. [PDF]
CellFollowing eukaryotic genome replication, the ring-shaped cohesin complex embraces the two newly synthesized sister chromatids, enabling their faithful segregation during cell divisions.
Glaser S +3 more
europepmc +2 more sources
A Replisome’s journey through the bacterial chromosome
Frontiers in Microbiology, 2015 Genome duplication requires the coordinated activity of a multi-component machine, the replisome. In contrast to the background of metabolic diversity across the bacterial domain, the composition and architecture of the bacterial replisome seems to have ...
Thomas Robert Beattie +1 more
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The replisome guides nucleosome assembly during DNA replication
Cell & Bioscience, 2020 Nucleosome assembly during DNA replication is tightly coupled to ongoing DNA synthesis. This process, termed DNA replication-coupled (RC) nucleosome assembly, is essential for chromatin replication and has a great impact on both genome stability ...
Wenshuo Zhang, Jianxun Feng, Qing Li
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