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Parental Histone Recycling During Chromatin Replication [PDF]
BiomoleculesThe past decade has seen significant advancement in our understanding of DNA replication-coupled chromatin assembly, especially parental histone recycling that is essential for epigenetic inheritance.
Xin Bi
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Replisomes restrict SMC translocation in vivo [PDF]
Nature CommunicationsStructural maintenance of chromosomes (SMC) complexes organize genomes by extruding DNA loops, while replisomes duplicate entire chromosomes. These essential molecular machines must collide frequently in every cell cycle, yet how such collisions are ...
Qin Liao +3 more
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ATP is dispensable for E. coli DNA replication and eukaryotic helicase activity [PDF]
Nature CommunicationsAdenosine triphosphate (ATP) hydrolysis is the main cellular source of energy used to drive biochemical reactions that are otherwise energetically unfavourable.
Richard R. Spinks +10 more
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Torsion is a dynamic regulator of DNA replication stalling and reactivation [PDF]
Nature CommunicationsDNA’s helical structure necessitates replisome rotation relative to DNA during replication, creating inevitable topological challenges. How replication generates and overcomes torsional stress remains unclear.
Xiaomeng Jia +9 more
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Viruses and the host replisome: discovering oncogenic mechanisms of small DNA tumor viruses [PDF]
Journal of VirologyHuman papillomavirus (HPV) and Merkel cell polyomavirus (MCPyV) are DNA tumor viruses that cause human cancer. The mechanisms by which HPV and MCPyV oncoproteins induce genomic instability are not well defined.
Christopher D. Collins +3 more
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Frontiers in Cell and Developmental Biology, 2021 In eukaryotes, the perfect duplication of the chromosomes is executed by a dynamic molecular machine called the replisome. As a key step to finishing DNA replication, replisome disassembly is triggered by ubiquitylation of the MCM7 subunit of the ...
Yisui Xia
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DNA replication machinery: Insights from in vitro single-molecule approaches
Computational and Structural Biotechnology Journal, 2021 The replisome is the multiprotein molecular machinery that replicates DNA. The replisome components work in precise coordination to unwind the double helix of the DNA and replicate the two strands simultaneously.
Rebeca Bocanegra +3 more
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Replication of the Mammalian Genome by Replisomes Specific for Euchromatin and Heterochromatin
Frontiers in Cell and Developmental Biology, 2021 Replisomes follow a schedule in which replication of DNA in euchromatin is early in S phase while sequences in heterochromatin replicate late. Impediments to DNA replication, referred to as replication stress, can stall replication forks triggering ...
Jing Zhang +8 more
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Mechanisms for Maintaining Eukaryotic Replisome Progression in the Presence of DNA Damage
Frontiers in Molecular Biosciences, 2021 The eukaryotic replisome coordinates template unwinding and nascent-strand synthesis to drive DNA replication fork progression and complete efficient genome duplication.
Thomas A. Guilliam
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Wellcome Open Research, 2023 Background: In eukaryotes, replication stress activates a checkpoint response, which facilitates genome duplication by stabilising the replisome. How the checkpoint kinases regulate the replisome remains poorly understood.
Andreas Hadjicharalambous +5 more
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