Results 111 to 120 of about 34,336 (231)

Cellular location and activity of Escherichia coli RecG proteins shed light on the function of its structurally unresolved C-terminus [PDF]

, 2014
RecG is a DNA translocase encoded by most species of bacteria. The Escherichia coli protein targets branched DNA substrates and drives the unwinding and rewinding of DNA strands.
Abd Wahab, Akeel A. Mahdi, Al-Deib, Amy L. Upton, Atkinson, Bachmann, Bernhardt, Bolt, Brendler, Briggs, Briggs, Buss, Christian J. Rudolph, Datsenko, David S. Milner, Gari, Geoffrey S. Briggs, Gregg, Gupta, Hong, Jaktaji, Jane I. Grove, Lau, Lecointe, Lesterlin, Lia, Lloyd, Lloyd, Lloyd, Machwe, Mahdi, Mahdi, Mahdi, Mahdi, Manosas, Marians, McGlynn, McGlynn, McGlynn, McGlynn, McGlynn, McGlynn, McGlynn, Michel, Parsons, Pomerantz, Ralf, Robert G. Lloyd, Rocha, Rudolph, Rudolph, Rudolph, Rudolph, Seigneur, Sharples, Shereda, Singleton, Sun, Trautinger, Tsaneva, Vincent, Waldminghaus, West, Whitby, Whitby, Whitby, Whitby, Zacharias, Zhang   +68 more
core   +2 more sources

Characterization of DnaB–DnaG Interaction in M. tuberculosis Using Small‐Angle X‐ray Scattering‐Based Dissociation Assay

ChemBioChem, Volume 26, Issue 14, July 18, 2025.
The study characterizes interactions between DnaB helicase and DnaG primase in Mycobacterium tuberculosis using small‐angle X‐ray scattering, surface plasmon resonance, and cross‐linking. The findings reveal that DnaG forms dimers in solution, which are destabilized upon DnaB binding.
Dayan A, Ilic S, Akabayov B
wiley   +1 more source

The Organisation of Replisomes

, 2011
The eukaryotic chromosomal DNA is divided into hundreds to thousands of independent replication segments called replicons. Each replicon is replicated from one replication origin. In the S phase of the cell cycle, individual replicons are gradually activated and subsequently replicated (Edenberg & Huberman, 1975; Hand, 1978).
Anna Ligasova, Karel Kober
openaire   +4 more sources

Chromosome organization shapes replisome dynamics in Caulobacter crescentus

Nature Communications
DNA replication in bacteria takes place on highly compacted chromosomes, where segregation, transcription, and repair must occur simultaneously. Within this dynamic environment, colocalization of sister replisomes has been observed in many bacterial ...
Chen Zhang, Asha Mary Joseph, Laurent Casini, Justine Collier, Anjana Badrinarayanan, Suliana Manley   +5 more
doaj   +1 more source

Coordinated degradation of replisome components ensures genome stability upon replication stress in the absence of the replication fork protection complex.

PLoS Genetics, 2013
The stabilization of the replisome complex is essential in order to achieve highly processive DNA replication and preserve genomic integrity. Conversely, it would also be advantageous for the cell to abrogate replisome functions to prevent inappropriate ...
Laura C Roseaulin, Chiaki Noguchi, Esteban Martinez, Melissa A Ziegler, Takashi Toda, Eishi Noguchi   +5 more
doaj   +1 more source

The dynamics of genome replication using deep sequencing [PDF]

, 2013
Peer reviewedPublisher ...
Agier, Alessandro P.S. de Moura, Alvino, Besnard, Bouton, Breier, Carolin A. Müller, Celniker, Chang, Conrad A. Nieduszynski, Cosgrove, Crampton, de Moura, De Piccoli, Di Rienzi, Eaton, Feng, Friedman, Gilbert, Hoggard, Huang, Katsuhiko Shirahige, Kearsey, Knott, Knott, Koren, Koren, Liachko, Lian, Makiko Komata, Martin J. Blythe, McGuffee, Mechali, Mechali, Mesner, Michelle Hawkins, Muller, Nakato, Natsume, Newman, Ng, Nieduszynski, Palzkill, Raghuraman, Ray Wilson, Renata Retkute, Retkute, Retkute, Rhind, Rudolph, Ryuichiro Nakato, Sekedat, Sharma, Shirahige, Siow, Sunir Malla, Theis, Theis, Theis, Vujcic, Xu, Xu, Yabuki, Yamashita, Yoshikawa   +64 more
core   +3 more sources

Compact Origins and Where to Find Them: ORC's Guide to Genome‐Wide Licensing

BioEssays, Volume 47, Issue 7, July 2025.
Origin licensing is a key requirement for any eukaryotic cell to initiate DNA replication in S‐phase. Here, we review the most recent findings in the orchestrated action of the origin recognition complex (ORC) to sequentially load two MCM2‐7 helicases onto DNA with a focus on origin architecture and sequencing‐based methods.
Christian Speck, Luitpold Maximilian Reuter   +1 more
wiley   +1 more source

The Replisome Mediates A-NHEJ Repair of Telomeres Lacking POT1-TPP1 Independently of MRN Function

Cell Reports, 2019
Summary: Telomeres use shelterin to protect chromosome ends from activating the DNA damage sensor MRE11-RAD50-NBS1 (MRN), repressing ataxia-telangiectasia, mutated (ATM) and ATM and Rad3-related (ATR) dependent DNA damage checkpoint responses.
Rekha Rai, Peili Gu, Cayla Broton, Chandan Kumar-Sinha, Yong Chen, Sandy Chang   +5 more
doaj   +1 more source

Modulation of DNA damage tolerance in Escherichia coli recG and ruv strains by mutations affecting PriB, the ribosome and RNA polymerase [PDF]

, 2012
RecG is a DNA translocase that helps to maintain genomic integrity. Initial studies suggested a role in promoting recombination, a possibility consistent with synergism between recG and ruv null alleles and reinforced when the protein was shown to unwind
Asai T., Cashel M., Guterman S.K., LeBowitz J.H., Lloyd R.G., Miller J.H., Sandler S.J., Sandler S.J., Tougu K.   +8 more
core   +2 more sources

Replisome bypass of a protein-based R-loop block by Pif1

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance The replisome machine that duplicates the DNA genome encounters a variety of blocks to replication, such as DNA bound proteins, R-loops, and DNA lesions.
G. Schauer, L. Spenkelink, Jacob S. Lewis, O. Yurieva, Stefan H. Mueller, Antoine M. van Oijen, M. O’Donnell   +6 more
semanticscholar   +1 more source