Results 121 to 130 of about 34,336 (231)

A Bacteriophage‐Derived Primase‐Helicase Orchestrates Plant Organellar DNA Replication

Physiologia Plantarum, Volume 177, Issue 4, July/August 2025.
ABSTRACT The mechanisms underlying the assembly and regulation of enzymatic complexes responsible for plant organellar DNA replication remain poorly characterized. Unlike the monophyletic origin of the gene products involved in animal mitochondrial replication, derived from T‐odd bacteriophages, plant organellar DNA replication relies on genes either ...
Carlos M. Morales‐Vázquez, Mayra A. Dagio‐Hernandez, Laura D. Camacho‐Manriquez, Antolin Peralta‐Castro, Claudia D. Raygoza, Diana Solano‐Argüello, Josue D. Mora‐Garduño, Rogelio Gonzalez‐Gonzalez, Humberto Herrera‐Ubaldo, Corina Díaz‐Quezada, Alfredo Cruz‐Ramírez, Stefan de Folter, José Antonio Pedroza‐García, Luis G. Brieba   +13 more
wiley   +1 more source

The conserved C-terminus of the PcrA/UvrD helicase interacts directly with RNA polymerase [PDF]

, 2013
Copyright: © 2013 Gwynn et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source ...
A Alzu, A Niedziela-Majka, A Urban, Abigail J. Smith, AJ Smith, AM Deaconescu, C Bruand, C Chen, Colin P. Guy, CP Guy, D Dutta, D Ursic, DB Srivastava, DE Kim, DT Jones, Emma J. Gwynn, G Shaw, GE Crooks, H Boubakri, H Jia, HE Mischo, HM Arthur, HS Subramanya, I Moszer, J Atkinson, J Atkinson, JS Finkel, JS Papadopoulos, JT Reardon, JT Yeeles, JY Lee, K Skourti-Stathaki, L Manelyte, LE Bird, LE Mechanic, LF Westblade, MA Petit, MA Petit, Maria Spies, Mark S. Dillingham, MC Hall, ME Fairman-Williams, MF Noirot-Gros, MF Noirot-Gros, MR Singleton, MS Dillingham, MS Dillingham, Nigel J. Savery, NJ Savery, NS Gilhooly, O Delumeau, O Yüce, P McGlynn, P Soultanas, P Soultanas, Peter McGlynn, R Kanagaraj, RC Centore, RR Iyer, S Iordanescu, S Korolev, SS Velankar, TM Lohman, V Epshtein, W Yang, X Veaute, Y Qi, Y Yang, Z Ni   +68 more
core   +8 more sources

A chromatinized origin reduces the mobility of ORC and MCM through interactions and spatial constraint

Nature Communications, 2023
Chromatin replication involves the assembly and activity of the replisome within the nucleosomal landscape. At the core of the replisome is the Mcm2-7 complex (MCM), which is loaded onto DNA after binding to the Origin Recognition Complex (ORC). In yeast,
Humberto Sánchez, Zhaowei Liu, Edo van Veen, Theo van Laar, John F. X. Diffley, Nynke H. Dekker   +5 more
doaj   +1 more source

The Swr1 chromatin-remodeling complex prevents genome instability induced by replication fork progression defects. [PDF]

, 2018
Genome instability is associated with tumorigenesis. Here, we identify a role for the histone Htz1, which is deposited by the Swr1 chromatin-remodeling complex (SWR-C), in preventing genome instability in the absence of the replication fork/replication ...
Branzei, Dana, Kolodner, Richard D, Li, Bin-Zhong, Putnam, Christopher D, Srivatsan, Anjana, Szakal, Barnabas   +5 more
core   +2 more sources

Maintaining the Integral Membrane Proteome: Revisiting the Functional Repertoire of Integral Membrane Proteases

ChemBioChem, Volume 26, Issue 9, May 5, 2025.
Regulated intramembrane proteolysis is crucial for functional proteome in all kingdoms of life. The task of cleaving transmembrane proteins within the unique environment of the lipid bilayer presents biochemical challenges that has been solved by integral membrane proteases (IMPRs).
Hannah Fremlén, Björn M. Burmann
wiley   +1 more source

Chimeric DNA byproducts in strand displacement amplification using the T7 replisome.

PLoS ONE, 2022
Recent advances in next generation sequencing technologies enable reading DNA molecules hundreds of kilobases in length and motivate development of DNA amplification methods capable of producing long amplicons.
Dillon B Nye, Nathan A Tanner
doaj   +1 more source

Characterization of a Triple DNA Polymerase Replisome [PDF]

Molecular Cell, 2007
The replicase of all cells is thought to utilize two DNA polymerases for coordinated synthesis of leading and lagging strands. The DNA polymerases are held to DNA by circular sliding clamps. We demonstrate here that the E. coli DNA polymerase III holoenzyme assembles into a particle that contains three DNA polymerases.
McInerney, Peter, Johnson, Aaron, Katz, Francine, O'Donnell, Mike   +3 more
openaire   +2 more sources

AmNA‐Modified Antisense Oligonucleotide Targeting MCM8 as a Cancer‐Specific Chemosensitizer for Platinum Compounds

Cancer Science, Volume 116, Issue 5, Page 1405-1416, May 2025.
MCM8‐9 functions in the repair of double‐strand breaks induced by replication stress, which is typically elevated in cancer cells. The authors developed an amido‐bridged nucleic acid‐modified gapmer antisense oligonucleotide, termed ASO 8–3419, to inhibit MCM8.
Yuki Uchibori, Masaki Suekuni, Yuko Kokaji, Kazumasa Yoshida, Tohru Kiyono, Yuuya Kasahara, Masatoshi Fujita   +6 more
wiley   +1 more source

The DNA-Binding Domain of S. pombe Mrc1 (Claspin) Acts to Enhance Stalling at Replication Barriers.

PLoS ONE, 2015
During S-phase replication forks can stall at specific genetic loci. At some loci, the stalling events depend on the replisome components Schizosaccharomyces pombe Swi1 (Saccharomyces cerevisiae Tof1) and Swi3 (S. cerevisiae Csm3) as well as factors that
Juergen Zech, Emma Louise Godfrey, Hisao Masai, Edgar Hartsuiker, Jacob Zeuthen Dalgaard   +4 more
doaj   +1 more source

Oxidative DNA damage stalls the human mitochondrial replisome [PDF]

, 2016
Oxidative stress is capable of causing damage to various cellular constituents, including DNA. There is however limited knowledge on how oxidative stress influences mitochondrial DNA and its replication.
Burgers, Peter M, Forslund, Josefin, Makarova, Alena V, Stojkovič, Gorazd, Wanrooij, Paulina H, Wanrooij, Sjoerd   +5 more
core   +2 more sources