Results 131 to 140 of about 34,336 (231)

High intrinsic hydrolytic activity of cyanobacterial RNA polymerase compensates for the absence of transcription proofreading factors [PDF]

, 2020
The vast majority of organisms possess transcription elongation factors, the functionally similar bacterial Gre and eukaryotic/archaeal TFIIS/TFS. Their main cellular functions are to proofread errors of transcription and to restart elongation via ...
James, Katherine, Riaz-Bradley, Amber, Yuzenkova, Yulia   +2 more
core   +2 more sources

Mitotic replisome disassembly in vertebrates [PDF]

, 2018
ABSTRACTRecent years have brought a breakthrough in our understanding of the process of eukaryotic DNA replication termination. We have shown that the process of replication machinery (replisome) disassembly at the termination of DNA replication forks in S-phase of the cell cycle is driven through polyubiquitylation of one of the replicative helicase ...
Moreno, Sara Priego, Jones, Rebecca M., Poovathumkadavil, Divyasree, Gambus, Agnieszka   +3 more
openaire   +1 more source

Progesterone Enhances Sensitivity of Ovarian Cancer Cells to SN38 Through Inhibition of Topoisomerase I and Inducing Ferroptosis

Cancer Reports, Volume 8, Issue 4, April 2025.
ABSTRACT Background Progesterone rapidly induces ovarian cancer cell death through non‐genomic actions mediated by the membrane progesterone receptor (mPR). Aims We investigated the combined effects of progesterone and SN38, an active metabolite of irinotecan, on ovarian cancer cells. Methods and Results mPR‐positive and PR‐negative ovarian cancer cell
Takahiro Koyanagi, Yasushi Saga, Yoshifumi Takahashi, Kohei Tamura, Eri Suizu, Suzuyo Takahashi, Akiyo Taneichi, Yuji Takei, Hiroaki Mizukami, Hiroyuki Fujiwara   +9 more
wiley   +1 more source

Dynamics of the Eukaryotic Replicative Helicase at Lagging-Strand Protein Barriers Support the Steric Exclusion Model

Cell Reports, 2019
Summary: Progression of DNA replication depends on the ability of the replisome complex to overcome nucleoprotein barriers. During eukaryotic replication, the CMG helicase translocates along the leading-strand template and unwinds the DNA double helix ...
Hazal B. Kose, Nicolai B. Larsen, Julien P. Duxin, Hasan Yardimci   +3 more
doaj   +1 more source

Innovative Wirkstoffe aus der antibakteriellen Forschung im Kampf gegen mikrobielle Resistenzen

Angewandte Chemie, Volume 137, Issue 10, March 3, 2025.
Dieser Artikel gewährt einen Überblick über in den letzten drei Jahrzehnten untersuchte antibakteriellen Wirkstoffe. Aspekte der Herkunft, der zellulären Targetstrukturen, des antibakteriellen Wirkspektrums und dem Nachweis der Wirksamkeit in Tierstudien werden zusammen mit aktuellen Entwicklungen beleuchtet.
Roderich D. Süssmuth, Marcel Kulike‐Koczula, Peng Gao, Simone Kosol   +3 more
wiley   +1 more source

The dynamic nature and territory of transcriptional machinery in the bacterial chromosome

Frontiers in Microbiology, 2015
Our knowledge of the regulation of genes involved in bacterial growth and stress responses is extensive; however, we have only recently begun to understand how environmental cues influence the dynamic, three-dimensional distribution of RNA polymerase ...
Ding Jun Jin, Cedric eCagliero, Carmen eMata Martin, Jerome eIzard, Yan Ning eZhou   +4 more
doaj   +1 more source

Replisome bypass of transcription complexes and R-loops

Nucleic Acids Research, 2020
The vast majority of the genome is transcribed by RNA polymerases. G+C-rich regions of the chromosomes and negative superhelicity can promote the invasion of the DNA by RNA to form R-loops, which have been shown to block DNA replication and promote ...
Jan-Gert Brüning, K. Marians
semanticscholar   +1 more source

Fighting Antimicrobial Resistance: Innovative Drugs in Antibacterial Research

Angewandte Chemie International Edition, Volume 64, Issue 10, March 3, 2025.
This article provides an overview over antibacterial drugs investigated in the past three decades. Aspects of the compound's origins, their cellular targets, the antibacterial spectrum and proof‐of‐concept in animal studies are covered and current trends are highlighted.
Roderich D. Süssmuth, Marcel Kulike‐Koczula, Peng Gao, Simone Kosol   +3 more
wiley   +1 more source

Identification and application of herbicide‐resistant 4‐hydroxyphenylpyruvate dioxygenase (HPPD) alleles via directed evolution

Plant Biotechnology Journal, Volume 23, Issue 10, Page 4336-4338, October 2025.
Bingbing Zhao, Yao Wang, Miaoyi Zhou, Xinxiang Liu, Hanshuai Li, Zi Shi, Yuhui Guo, Ting Li, Fengling Yang, Ronghuan Wang, Jiuran Zhao, Ya Liu   +11 more
wiley   +1 more source

Regulation of DNA Topology in Archaea: State of the Art and Perspectives

Molecular Microbiology, Volume 123, Issue 3, Page 245-264, March 2025.
DNA topoisomerases are ubiquitous enzymes that play a crucial role in regulating DNA supercoiling which affects fundamental biological processes involving DNA. In this review, we summarize the current understanding of regulation of supercoiling by DNA topoisomerases in the third domain of life, the Archaea, with a particular focus on three key model ...
Paul Villain, Tamara Basta
wiley   +1 more source