Results 221 to 230 of about 100,632 (325)

Towards human cardiac new approach methodologies (NAMs) to evaluate the combination of repolarization prolonging and shortening drugs: a pilot study. [PDF]

Front Drug Discov (Lausanne)
Geiger RM, Serna C, Bhardwaj B, Feaster TK, Blinova K.   +4 more
europepmc   +1 more source

Models of cardiomyocyte–non‐myocyte electrical interactions

The Journal of Physiology, EarlyView.
Abstract figure legend Cardiomyocyte–non‐myocyte (CM–NM) electrotonic coupling. Left: conceptual contact‐based interactions between CM and other NM via connexin (Cx) proteins. Three basic scenarios are proposed: (i) ‘zero‐sided coupling’ where there are no electrical connections between CM and NM, (ii) ‘single‐sided coupling’ where NM are connected to ...
Ana Simon‐Chica, Axel Loewe, Peter Kohl   +2 more
wiley   +1 more source

Corrigendum: The Electrogenic Na+/K+ Pump Is a Key Determinant of Repolarization Abnormality Susceptibility in Human Ventricular Cardiomyocytes: A Population-Based Simulation Study

Frontiers in Physiology, 2017
Oliver J. Britton, Alfonso Bueno-Orovio, László Virág, András Varró, Blanca Rodriguez   +4 more
doaj   +1 more source

Mathematical model of the zebrafish ventricular cardiomyocyte action potential and calcium transient

The Journal of Physiology, EarlyView.
Abstract figure legend This study presents the development and validation of the first biophysically detailed computational model of the zebrafish ventricular action potential (AP). The model is based on a human cardiomyocyte framework and reparameterized using published and newly generated patch‐clamp recordings of zebrafish ionic currents.
Ludovica Cestariolo, Zachary D. Long, Arie O. Verkerk, Jose M. Ferrero, T. Alexander Quinn, Jose F. Rodriguez Matas   +5 more
wiley   +1 more source

Transmural APD gradient synchronizes repolarization in the human left ventricular wall.

Cardiovascular Research, 2015
B. Boukens, M. Sulkin, C. Gloschat, F. Ng, E. Vigmond, I. Efimov   +5 more
semanticscholar   +1 more source

Mechanisms underlying local Ca2+ signalling differences between right and left atrial myocytes at normal and increased frequencies

The Journal of Physiology, EarlyView.
Abstract figure legend Left atrial myocytes have TAT‐associated faster Ca2+ release but are more prone to maladaptation at higher frequencies due to weaker peripheral SR Ca2+ uptake and smaller trigger Ca2+ current. Abstract Changes in heart rate affect Ca2+ signalling and contractility in ventricular muscle, but the effects on atrial Ca2+ signalling ...
Joon‐Chul Kim, Hieu Trong Huynh, Phuong Kim Luong, Tran Nguyet Trinh, Yixuan Wu, Eleonora Grandi, Sun‐Hee Woo   +6 more
wiley   +1 more source

Detailed Association Between Electrocardiogram Abnormality and Primary Myocardial Fibrosis. [PDF]

Clin Cardiol
Nomoto Y, Kataoka N, Imamura T.
europepmc   +1 more source

Early repolarization pattern with oral liquid nicotine. [PDF]

BMC Cardiovasc Disord
Wolfes J, Reitnauer L, Eckardt L.
europepmc   +1 more source

J-wave syndromes: Brugada and early repolarization syndromes.

Heart Rhythm, 2015
C. Antzelevitch, G. Yan
semanticscholar   +1 more source

Electrophysiological characterization of pre‐adolescents born with intrauterine growth restriction: insights from clinical and computational data

The Journal of Physiology, EarlyView.
Abstract figure legend Depolarization and repolarization duration analysis was conducted in preadolescent groups with IUGR and controls using a 12‐lead ECG. Principal component analysis was applied over the 12‐lead ECGs to generate spatially transformed leads better suited for robust ECG fiducial points detection.
Freddy L. Bueno‐Palomeque, Ernesto Zacur, Esther Pueyo, Fàtima Crispi, Pablo Laguna, Ana Mincholé   +5 more
wiley   +1 more source