Results 61 to 70 of about 100,632 (325)

Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study [PDF]

, 2007
BACKGROUND: Heritable electrocardiographic (ECG) and heart rate variability (HRV) measures, reflecting pacemaking, conduction, repolarization and autonomic function in the heart have been associated with risks for cardiac arrhythmias.
Guo, Chao-Yu, Larson, Martin G., Levy, Daniel, Newton-Cheh, Christopher, O'Donnell, Christopher J., Wang, Thomas J.   +5 more
core   +4 more sources

Mechanical and Electrical Phenotype of hiPSC‐Cardiomyocytes on Fibronectin‐Based Hydrogels

Advanced Healthcare Materials, EarlyView.
We introduce fibronectin‐based PEG hydrogels with controlled rigidity to enable the culture of iPSC‐derived cardiomyocytes. These substrates offer an alternative to the current culture of these cells on fibronectin‐coated glass, providing enhanced structural and functional behavior. The system provides a more physiologically relevant platform to assess
Ana Da Silva Costa, Lineta Stonkute, Sara Trujillo, Mariana Azevedo Gonzalez Oliva, Francis Burton, Matthew J. Dalby, Oana Dobre, Godfrey Smith, Manuel Salmeron‐Sanchez   +8 more
wiley   +1 more source

β-adrenergic stimulation augments transmural dispersion of repolarization via modulation of delayed rectifier currents IKs and IKr in the human ventricle

Scientific Reports, 2017
Long QT syndrome (LQTS) is an inherited or drug induced condition associated with delayed repolarization and sudden cardiac death. The cardiac potassium channel, IKr, and the adrenergic-sensitive cardiac potassium current, IKs, are two primary ...
C. Kang, C. Kang, A. Badiceanu, J. Brennan, Christopher R Gloschat, Christopher R Gloschat, Yun Qiao, Yun Qiao, Natalia A. Trayanova, I. R. Efimov, I. R. Efimov   +10 more
semanticscholar   +1 more source

Percutaneous pulmonary valve implantation alters electrophysiologic substrate [PDF]

, 2016
BACKGROUND: Percutaneous pulmonary valve implantation (PPVI) is first‐line therapy for some congenital heart disease patients with right ventricular outflow tract dysfunction.
Avari Silva, Jennifer N, Balzer, David T, Nguyen, Hoang H, Nicolas, Ramzi, Shahanavaz, Shabana, Van Hare, George F   +5 more
core   +2 more sources

Sex, hormones, and repolarization [PDF]

Cardiovascular Research, 2002
There is increased awareness of the impact of gender and gonadal steroids on human cardiac rhythm and arrhythmias; e.g., drugs that prolong repolarization induce torsades de pointes (TdP) more frequently in women than men; female gender is an independent risk factor for syncope and sudden death in the congenital long QT syndrome; and the higher ...
Thai V, Pham, Michael R, Rosen
openaire   +2 more sources

Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges

Advanced Healthcare Materials, EarlyView.
This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad, Yasmine Ruel, Roxane Pouliot, Davide Brambilla   +3 more
wiley   +1 more source

T‐wave heterogeneity in standard resting 12‐lead ECGs is associated with 90‐day cardiac mortality in women following emergency department admission: A nested case–control study

Annals of Noninvasive Electrocardiology, 2021
Background We investigated whether T‐wave heterogeneity (TWH) can identify patients who are at risk for near‐term cardiac mortality. Methods A nested case–control analysis was performed in the 888 patients admitted to the Emergency Department (ED) of our
Felipe R. Monteiro, Ana B. Rabelo Evangelista, Bruce D. Nearing, Sofia A. Medeiros, Fernanda Tessarolo Silva, Giovanna C. Pedreira, Edward Ullman, Ernest V. Gervino, Richard L. Verrier   +8 more
doaj   +1 more source

Acetylcholine Reduces L-Type Calcium Current without Major Changes in Repolarization of Canine and Human Purkinje and Ventricular Tissue

Biomedicines, 2022
Vagal nerve stimulation (VNS) holds a strong basis as a potentially effective treatment modality for chronic heart failure, which explains why a multicenter VNS study in heart failure with reduced ejection fraction is ongoing.
Arie O. Verkerk, Illés J. Doszpod, Isabella Mengarelli, Tibor Magyar, Alexandra Polyák, Bence Pászti, Igor R. Efimov, Ronald Wilders, István Koncz   +8 more
doaj   +1 more source

An In Situ Embedded B‐MOF Sponge With Shape‐Memory for All‐in‐One Diabetic Wound Therapy

Advanced Healthcare Materials, EarlyView.
A smart shape‐memory sponge dressing (P1A3@B‐MOF) is developed for accelerated diabetic wound healing. It achieves pH‐responsive corelease of Zn2+ and salvianolic acid B, synergistically providing antibacterial action, repolarizing macrophages to the M2 phenotype, and promoting angiogenesis.
Hai Zhou, Chaoyang Huang, Yanqi Chen, Tingzi Zhao, Fengyi Zhu, Gong Jun, Jinrong Zhang, Yingsong Pan, Qiulan Wen, Lei Yang, Huihui Zhang, Lianglong Chen   +11 more
wiley   +1 more source

Analysis of 24-h Rhythm in Ventricular Repolarization Identifies QT Diurnality As a Novel Clinical Parameter Associated with Previous Ventricular Arrhythmias in Heart Failure Patients

Frontiers in Physiology, 2017
Introduction: Cardiac repolarization abnormalities are among the major causes of ventricular arrhythmias and sudden cardiac death. In humans, cardiac repolarization duration has a 24-h rhythm.
Bastiaan C. Du Pre, Bastiaan C. Du Pre, Linda W. Van Laake, Matthias Meine, Jeroen F. Van der Heijden, Pieter A. Doevendans, Marc A. Vos, Toon A. B. Van Veen   +7 more
doaj   +1 more source