Results 41 to 50 of about 58,408 (249)

Restricting excessive cardiac action potential and QT prolongation: a vital role for IKs in human ventricular muscle [PDF]

, 2005
Background - Although pharmacological block of the slow, delayed rectifier potassium current (I-Ks) by chromanol 293B, L-735,821, or HMR-1556 produces little effect on action potential duration (APD) in isolated rabbit and dog ventricular myocytes, the ...
Lengyel, Csaba Attila, Varró, András, Takács, János, Bogáts, Gábor, Nagy, Zsolt, Lathrop, David A., Biliczki, Péter, Bitay, Miklós, Jost, Norbert, Virág, László, Papp, Gyula   +10 more
core   +1 more source

Understanding repolarization in the intracardiac unipolar electrogram: A long-lasting controversy revisited

Frontiers in Physiology, 2023
Background: The optimal way to determine repolarization time (RT) from the intracardiac unipolar electrogram (UEG) has been a topic of debate for decades.
Job Stoks, Job Stoks, Job Stoks, Laura R. Bear, Johan Vijgen, Paul Dendale, Ralf Peeters, Paul G. A. Volders, Matthijs J. M. Cluitmans   +8 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Manifested U‐Waves Prior to Seizure Attacks in a Patient Who Had Remote Subarachnoid Hemorrhage: A Case Report

Annals of Noninvasive Electrocardiology
Sudden unexpected death in epilepsy (SUDEP) refers to unpredictable demise of a person following a seizure. Electroencephalograms can directly measure electrical activity in the brain; however, it cannot predict when seizures will occur.
Nao Kaneko, Masao Watanabe, Shusuke Mori, Isik Turker, Ken Okamoto, Takao Urabe, Tomohiko Ai   +6 more
doaj   +1 more source

The Effects of Pediatric Acute Lymphoblastic Leukemia Treatment on Cardiac Repolarization

Children
Background: In recent years, cardiac dysfunction in childhood cancer survivors has become an important issue. Studies are focusing on identifying means for the early identification of patients at risk.
Diana R. Lazar, Simona Cainap, Florin Leontin Lazar, Dana Maniu, Cristina Blag, Madalina Bota, Marius C. Colceriu, Mihnea Zdrenghea   +7 more
doaj   +1 more source

An Innervated Human Skin Equivalent that Electrically Encodes Mechanical and Thermal Stimuli

Advanced Science, EarlyView.
An innervated human skin equivalent is integrated with high‐density microelectrode arrays to reveal how engineered free nerve ending–like structures translate touch and temperature into electrical codes. Mechanical indentation and thermal stimulation engage the engineered somatosensory circuitry and evoke distinct firing and waveform signatures ...
Daniele Bellantoni, Costantino Casale, Marika Sperduti, Nevio L. Tagliamonte, Giorgia Imparato, Loredana Zollo, Paolo A. Netti   +6 more
wiley   +1 more source

Comparison of Electrocardiographic Repolarization Patterns between Hypogonad Males and Normal Subjects

Annals of Noninvasive Electrocardiology, 2003
Background: There is a significant difference in repolarization on the surface ECG between men and women. The effect of testosterone on repolarization of myocardium may provide a basis for the physiological and pathophysiological importance of these ...
Ata Kirilmaz, Erol Bolu, Fethi Kilicaslan, Kursad Erinc, Mehmet Uzun, Ersoy Isik, Metin Ozata, Caglayan Ozdemir, Ertan Demirtas   +8 more
doaj   +1 more source

High prevalence of altered cardiac repolarization in patients with COPD [PDF]

, 2014
BACKGROUND: Altered cardiac repolarization and increased dispersion of repolarization have been identified as risk factors for sudden cardiac death (SCD).
Kohler, Malcolm, Clarenbach, Christian F., Clarenbach, Christian F, Christian F Clarenbach, Sievi, Noriane A, Noriane A Sievi, van Gestel, Arnoldus J R, Rossi, Valentina A., Rossi, Valentina A, Arnoldus JR van Gestel, Sievi, Noriane A., Malcolm Kohler, Valentina A Rossi, van Gestel, Arnoldus J.R., Giovanni Camen, Camen, Giovanni, Kohler M, Camen G, Sievi NA, Rossi VA, Clarenbach CF, van Gestel AJ   +21 more
core   +2 more sources

Chemical Bond‐Orchestrated Energy Depletion to Augment Lung Cancer Chemo‐Immunotherapy

Advanced Science, EarlyView.
This study grafted dichloroacetic acid (DCA) into perylenediimide (PDI) skeleton via ionic or covalent bond to create novel metabolic agent PDIC‐AC and PDIC‐NAC, explicitly elaborated the underlying energy metabolism and therapeutic mechanism, and developed a promising strategy for energy metabolism‐targeting chemo‐immunotherapy by chemical bond ...
Xuejie Zhao, Yuting Liu, Xiao Huang, Liwen Zhao, Chunli Li, Yongwei Huang   +5 more
wiley   +1 more source

Role of abnormal repolarization in the mechanism of cardiac arrhythmia [PDF]

, 2017
In cardiac patients, life-threatening tachyarrhythmia is often precipitated by abnormal changes in ventricular repolarization and refractoriness. Repolarization abnormalities typically evolve as a consequence of impaired function of outward K(+) currents
Osadchii, Oleg, O. E. Osadchii, Osadchiy, Oleg   +2 more
core   +1 more source