Results 51 to 60 of about 57,164 (287)

From Cell‐Derived Vesicles to Hybrid Nanovectors: Biological Membranes as Functional Blueprints for Gene Delivery

Advanced Healthcare Materials, EarlyView.
Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari, Claudia Leone, Gabriella Leccese, Claudia De Stradis, Alessandra Invidia, Concetta Quintarelli, Biagio De Angelis, Franco Locatelli, Giuseppe Gigli, Gabriele Maiorano, Ilaria Elena Palamà   +10 more
wiley   +1 more source

Restricting excessive cardiac action potential and QT prolongation: a vital role for IKs in human ventricular muscle [PDF]

, 2005
Background - Although pharmacological block of the slow, delayed rectifier potassium current (I-Ks) by chromanol 293B, L-735,821, or HMR-1556 produces little effect on action potential duration (APD) in isolated rabbit and dog ventricular myocytes, the ...
Lengyel, Csaba Attila, Varró, András, Takács, János, Bogáts, Gábor, Nagy, Zsolt, Lathrop, David A., Biliczki, Péter, Bitay, Miklós, Jost, Norbert, Virág, László, Papp, Gyula   +10 more
core   +1 more source

Understanding repolarization in the intracardiac unipolar electrogram: A long-lasting controversy revisited

Frontiers in Physiology, 2023
Background: The optimal way to determine repolarization time (RT) from the intracardiac unipolar electrogram (UEG) has been a topic of debate for decades.
Job Stoks, Job Stoks, Job Stoks, Laura R. Bear, Johan Vijgen, Paul Dendale, Ralf Peeters, Paul G. A. Volders, Matthijs J. M. Cluitmans   +8 more
doaj   +1 more source

Targeting CD300a Signaling With a Phosphatidylserine‐Presenting Hydrogel Rescues Macrophage Dysfunction and Accelerates Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the proposed mechanism: PEG/RGD‐PSLs mimic apoptotic cells to engage PS receptors (notably CD300a), transducing an inhibitory signal that suppresses the MyD88/NF‐κB pathway, leading to global anti‐inflammatory and pro‐reparative effects.
Lele Wu, Xuetong Hao, Yang Zou, Xinglin Chen, Junyan Kong, Chunning Gu, Wenjie Ma, Zhongjun Yang, Huifen Liu, Mengmeng Liu, Xin Tong   +10 more
wiley   +1 more source

Manifested U‐Waves Prior to Seizure Attacks in a Patient Who Had Remote Subarachnoid Hemorrhage: A Case Report

Annals of Noninvasive Electrocardiology
Sudden unexpected death in epilepsy (SUDEP) refers to unpredictable demise of a person following a seizure. Electroencephalograms can directly measure electrical activity in the brain; however, it cannot predict when seizures will occur.
Nao Kaneko, Masao Watanabe, Shusuke Mori, Isik Turker, Ken Okamoto, Takao Urabe, Tomohiko Ai   +6 more
doaj   +1 more source

The Effects of Pediatric Acute Lymphoblastic Leukemia Treatment on Cardiac Repolarization

Children
Background: In recent years, cardiac dysfunction in childhood cancer survivors has become an important issue. Studies are focusing on identifying means for the early identification of patients at risk.
Diana R. Lazar, Simona Cainap, Florin Leontin Lazar, Dana Maniu, Cristina Blag, Madalina Bota, Marius C. Colceriu, Mihnea Zdrenghea   +7 more
doaj   +1 more source

Blood–Brain Barrier Regulation: Evolving From Classic Strategies to Electrochemical Ion and Reactive Oxygen Species Control

Advanced Healthcare Materials, EarlyView.
Conventional therapies suffer from poor blood–brain barrier (BBB) penetration and disordered ion/reactive oxygen species (ROS) homeostasis, hindering precise neurological treatment. Electrochemical strategies achieve accurate spatiotemporal regulation of neural homeostasis.
Xiaokang Hu, Caiyu Liu, Meijun Pang, Zhiyuan Shi, Dong Ming, Xiuyun Liu   +5 more
wiley   +1 more source

Comparison of Electrocardiographic Repolarization Patterns between Hypogonad Males and Normal Subjects

Annals of Noninvasive Electrocardiology, 2003
Background: There is a significant difference in repolarization on the surface ECG between men and women. The effect of testosterone on repolarization of myocardium may provide a basis for the physiological and pathophysiological importance of these ...
Ata Kirilmaz, Erol Bolu, Fethi Kilicaslan, Kursad Erinc, Mehmet Uzun, Ersoy Isik, Metin Ozata, Caglayan Ozdemir, Ertan Demirtas   +8 more
doaj   +1 more source

Engineering Pluripotent Stem Cells‐Derived Inner Ear Organoids With Enhanced Maturation and Reproducibility by Micro‐Topographical Cues

Advanced Materials, EarlyView.
Micro‐topographical cues applied through temporally controlled microscale confinement improve the reproducibility, spatial organization, and neurosensory‐associated features of pluripotent stem cell‐derived inner ear organoids. Integration with a vascularized organoid platform further enables controlled investigation of vascular‐epithelial interactions
Harshita Sharma, Jungeun Lim, Woochan Kim, Yeon Ju Kim, Dream Kim, Shinyull Lee, Chaeyeon Park, Stephen Rhee, Shruthy Kuttapan, Jungho Ha, Sang Wook Park, Kyunghoon Kim, Noo Li Jeon, Sunho Park, Yun‐Hoon Choung, Jangho Kim   +15 more
wiley   +1 more source

Increased vulnerability of human ventricle to re-entrant excitation in hERG-linked variant 1 short QT syndrome [PDF]

, 2011
The short QT syndrome (SQTS) is a genetically heterogeneous condition characterized by abbreviated QT intervals and an increased susceptibility to arrhythmia and sudden death.
Hancox Jules C., McPate, Mark J., Mark J McPate, Hancox, Jules C., Witchel, HJ, Witchel Harry J., Witchel, Harry J., Ismail Adeniran, Zhang, H., Hancox, JC, McPate, MJW, Henggui Zhang (74233), Ismail Adeniran (192479), Adeniran, I., Adeniran, Ismail, Zhang Henggui, Adeniran Ismail, Zhang, Henggui, Henggui Zhang, Jules C Hancox, Harry Witchel (4462174), Jules C Hancox (16149998), McPate Mark J., Mark J McPate (16150001), Harry J Witchel   +24 more
core   +2 more sources