Results 91 to 100 of about 3,024,688 (292)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
On the Representation of Context
Semantics and Linguistic Theory, 1996 No abstract.
openaire +3 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
THE REPRESENTATION OF NATURE: AN ANALYSIS OF THE VIRTUAL REPRESENTATION OF NATURE AND ITS CHALLENGES
, 2010 In this thesis, I provide an analysis of the representation within the environmental movement that is based in critical theory. In considering the paradox which involves the awareness of an ecological crisis as well as a strong resistance to the ...
Sewell, Rebecca
core
On Medial Representations [PDF]
, 2008 During the last half century, medial representations of objects have been involved in many biological and physical theories, and computer scientists have designed suitable algorithms for their computation. Aim of this paper is to provide a short, non-comprehensive, survey of the most common medial representation systems.
openaire +4 more sources
Representation Levels Within Knowledge Representation [PDF]
, 2007 Representation of knowledge is used to store and retrieve informational data in a machine. Since meaningcannot be directly stored in the computer; this work proposes a series of levels of representation. The meaning of the data is transformed to a format that the machine can use to store and retrieve knowledge.
Heather D. Pfeiffer +1 more
openaire +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
, 2011 The utility of tones spaces based on tone productions can be judged on the degree to which they (i) differentiate tone productions and (ii) predict tone perception. Here based on a production corpus, 5 different 2-dimensional tone spaces are constructed.
Attina, Virginie (R14534) +3 more
core
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source