Results 61 to 70 of about 4,015,164 (338)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

An axiomatic theory of political representation [PDF]

Journal of Economic Theory, 2009
We discuss the theory of voting rules which are immune to gerrymandering. Our approach is axiomatic. We show that any rule that is unanimous, anonymous, and representative consistent must decide a social alternative as a function of the proportions of agents voting for each alternative, and must either be independent of this proportion, or be in one-to-
openaire   +5 more sources

Polydatin ameliorates ovalbumin‐induced asthma in a rat model through NCOA4‐mediated ferroautophagy and ferroptosis pathway

FEBS Open Bio, EarlyView.
In this research, a rat model of asthma was created using OVA, and polydatin served as an intervention. By inhibiting ferroautophagy mediated by NCOA4 and averting ferroptosis, polydatin has been demonstrated to reduce asthma. This work presents new ideas for investigating the mechanism of polydatin's ability to alleviate asthma, in addition to ...
Wei Li, Yuwei Tang, Wenkang Liu, Fang Fang, Jiepeng Wang, Chaoyi Fang   +5 more
wiley   +1 more source

Electing women to Parliament: Fiji and the alternative vote electoral system

Pacific Journalism Review, 2006
In many places in the world, women struggle to be heard and, when it comes to having a voice in the highest authority in the land, the difficulties in some countries can be almost insurmountable.
Rae Nicholl
doaj   +1 more source

Downregulation of sST2, a decoy receptor for interleukin‐33, enhances subcutaneous tumor growth in murine pancreatic cancer cells

FEBS Open Bio, EarlyView.
Subcutaneous implantation of murine Panc02 pancreatic cancer cells depleted of sST2, a soluble decoy receptor for the proinflammatory interleukin‐33 (IL‐33), leads to a decreased number of GLUT4‐positive cancer‐associated adipocytes, reduced levels of the anti‐inflammatory molecule adiponectin, increased phosphorylation of IκBα, elevated Cxcl3 ...
Miho Akimoto, Nobuko Koshikawa, Takao Morinaga, Mimi Tamamori‐Adachi, Atsushi Takatori, Keizo Takenaga   +5 more
wiley   +1 more source

The logic of representation in political rituals [PDF]

International Journal of Philosophy and Theology, 2018
Political rituals, like the sovereign acclamation described in Rousseau’s social contract, exhibit a logic of representation that seem to oscillate between presence and absence, and enact a problematic identification of the people as a multitude of individuals and as a whole.
openaire   +2 more sources

The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells

FEBS Open Bio, EarlyView.
We performed nanopore whole‐transcriptome sequencing comparing RNA from Hnrnpl‐knockdown versus control C2C12 myoblasts to investigate the contributions of Hnrnpl to muscle development. Our results indicate that Hnrnpl regulates the expression of genes involved with Notch signaling and skeletal muscle, particularly splicing patterns of specific muscle ...
Hannah R. Littel, Mekala Gunasekaran, Audrey L. Daugherty, Natalya M. Wells, Johnnie Turner, Christine C. Bruels, Christina A. Pacak, Isabelle Draper, Peter B. Kang   +8 more
wiley   +1 more source

O bacharel em direito como o homem público brasileiro

Mediações: Revista de Ciências Sociais, 2003
Law bachelors are, and always have been, the most widely represented class in brazilian politics. The constitution of the House of Representatives throughout history has reflected this reality since the Empire.
Humberto Dantas
doaj   +1 more source

Populism and feminist politics: The cases of Finland and Spain

European Journal of Political Research, 2019
While populism has been subject to growing scholarly interest, its relationship to feminist politics has remained conspicuously understudied. This article investigates this relationship by analysing two cases of European populism: left populism in Spain (
J. Kantola, Emanuela Lombardo
semanticscholar   +1 more source