Results 41 to 50 of about 569 (262)
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
GeoTextos, 2013 The present article aims at analyzing the spatiality proposed by the art exhibition “2012: propositions for the future”, taken place at the Museum of Contemporary Art in Curitiba/ Brazil.
Sibele Paulino
doaj
Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes
FEBS Letters, EarlyView.Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez +2 more
wiley +1 more source
Spatial representation in product modelling [PDF]
Proceedings Fifth International Conference on Information Visualisation, 2002 An unambiguous definition of space is necessary before any attempt is made to develop product or process models for concurrent engineering in the AEC Industry. The ambiguity is the result of different and even conflicting approaches to its definition in the various phases of the building life cycle for different stakeholders, e.g. architects, engineers,
Monjur M. Mourshed +2 more
openaire +1 more source
Age, Culture, Humanities, 2015 This paper addresses cultural constructions of old age in two contemporary Canadian care home narratives. While John Mighton’s play Half Life (2005) is set in a prison-like long-term care facility that is represented as a site of homogenization ...
Ulla Kriebernegg
doaj +1 more source
Transferts migratoires, institutions sociales migrantes et territorialité morale transnationale
L'Espace Politique, 2020 How do those who stayed behind exert their authority over emigrants (notably to make sure they keep on sending remittances) despite the distance? How does power circulate beyond borders?
Thomas Lacroix
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
L'Espace Politique, 2020 This article deals with the mechanism through which individuals or groups become geopolitical actors in distant conflicts, i.e. conflicts that do not take place on the territory where these people live.
Hervé Amiot
doaj +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source