Results 41 to 50 of about 1,013,866 (199)

Iron-Induced Oxidative Injury Differentially Regulates PI3K/Akt/GSK3β Pathway in Synaptic Endings from Adult and Aged Rats [PDF]

, 2009
In this work we study the state of phosphoinositide-3-kinase/Akt/glycogen synthase kinase 3 beta (PI3K/Akt/GSK3 beta) signaling during oxidative injury triggered by free iron using cerebral cortex synaptic endings isolated from adult (4-month-old) and ...
Giusto, Norma Maria, Salvador, Gabriela Alejandra, Uranga, Romina Maria   +2 more
core   +2 more sources

Development of the Indian Future Weather File Generator Based on Representative Concentration Pathways

Sustainability, 2022
India’s fossil-fuel-based energy dependency is up to 68%, with the commercial and residential sectors contributing to the rise of building energy demand, energy use, and greenhouse gas emissions. Several studies have shown that the increasing building energy demand is associated with increased space-cooling ownership and building footprint.
Naga Venkata Sai Kumar Manapragada, Anoop Kumar Shukla, Gloria Pignatta, Komali Yenneti, Deepika Shetty, Bibhu Kalyan Nayak, Venkataramana Boorla   +6 more
openaire   +1 more source

Toll-Like Receptor 4 Modulates Small Intestine Neuromuscular Function through Nitrergic and Purinergic Pathways [PDF]

, 2017
Objective: Toll-like receptors (TLRs) play a pivotal role in the homeostatic microflora-host crosstalk. TLR4-mediated modulation of both motility and enteric neuronal survival has been reported mainly for colon with limited information on the role of ...
Cecilia Giulivi, Cecilia Giulivi, Eleonora Napoli, Francesca Galuppini, Genny Orso, Ilaria Marsilio, Isabella Lante, Maria Cecilia Giron, Massimo Rugge, Mona Roozfarakh, Silvia Cerantola, Silvia Cerantola, Valentina Caputi   +12 more
core   +3 more sources

Optimal allocation model of the water resources in Harbin under representative concentration pathway scenarios [PDF]

Water Supply, 2020
AbstractWater conservation is a strategic choice for sustainable societal development. Rational planning and allocation of water resources is an effective way to improve the efficiency of water resource utilization. Taking Harbin as an example, this paper constructs a linear fractional programming model based on chance-constrained programming.
Fanxiang Meng, Linqi Li, Tianxiao Li, Qiang Fu   +3 more
openaire   +1 more source

Monitoring climate extremes using standardized evapotranspiration index and future projection of rainfall and temperature in the wettest parts of southwest Ethiopia

Environmental Challenges, 2022
Ethiopia is categorized as one of the most vulnerable countries to climate extremes. A better understanding of climate extremes at short and long timescales is therefore crucial to minimize the potential impacts of these extremes. The present study aimed
Dessalegn Obsi Gemeda, Diriba Korecha, Weyessa Garedew   +2 more
doaj   +1 more source

Intersecting vulnerabilities: climatic and demographic contributions to future population exposure to Aedes-borne viruses in the United States

Environmental Research Letters, 2020
Understanding how climate change and demographic factors may shape future population exposure to viruses such as Zika, dengue, or chikungunya, transmitted by Aedes mosquitoes is essential to improving public health preparedness. In this study, we combine
Guillaume Rohat, Andrew Monaghan, Mary H Hayden, Sadie J Ryan, Elodie Charrière, Olga Wilhelmi   +5 more
doaj   +1 more source

Potential distribution of crop wild relatives under climate change in Sri Lanka: implications for conservation of agricultural biodiversity

Current Research in Environmental Sustainability, 2021
The global population is growing rapidly and food production needs to be stepped up substantially to supply the additional demand expected by projected increased population.
Sujith S. Ratnayake, Champika S. Kariyawasam, Lalit Kumar, Danny Hunter, A.S.U. Liyanage   +4 more
doaj   +1 more source

The use of inhibitors to study endocytic pathways of gene carriers: optimization and pitfalls [PDF]

, 2010
Nonviral gene complexes can enter mammalian cells through different endocytic pathways. For efficient optimization of the gene carrier it is important to profile its cellular uptake, because this largely determines its intracellular processing and ...
Dries Vercauteren, Roosmarijn E Vandenbroucke, Arwyn T Jones, Joanna Rejman, Joseph Demeester, Stefaan C De Smedt, Niek N Sanders, Kevin Braeckmans, Wattiaux, Conner, Jones, Grimmer, Rejman, Widera, Maxfield, Mayor, Simons, Parton, Pelkmans, Torgersen, Puri, Singh, Marks, Zuhorn, Glebov, Medina-Kauwe, Khalil, Elouahabi, Midoux, von Gersdorff, Douglas, Wong, Gabrielson, Banks, Ivanov, Wang, Larkin, Rodal, Parton, Nabi, Gonçalves, Nichols, Hinrichsen, Huang, Vanden Broeck, Benmerah, Payne, Damke, Liu, Lamaze, Rejman, Mano, Weyermann, Subtil, Huth, Davis, Yuwen, Sonnichsen   +57 more
core   +3 more sources

Potential Impacts of Climate Change on the Al Abila Dam in the Western Desert of Iraq

Hydrology, 2023
The potential impacts resulting from climate change will cause significant global problems, particularly in underdeveloped nations where the effects are felt the most.
Rasha Abed, Ammar Adham, Mohammed Falah Allawi, Coen Ritsema   +3 more
doaj   +1 more source

Capsaicin triggers autophagic cell survival which drives epithelial mesenchymal transition and chemoresistance in bladder cancer cells in an Hedgehog-dependent manner [PDF]

, 2016
Bladder cancer (BC) is a common urologic tumor characterized by high risk of recurrence and mortality. Capsaicin (CPS), used as an intravesical drug for overactive bladder, was demonstrated to induce cell death in different cancer cells including BC ...
Amantini, C, CARDINALI, CLAUDIO, GISMONDI, Angela, MORELLI, MARIA BEATRICE, Nabissi, M, Santoni, G., Santoni, M   +6 more
core   +1 more source