Results 61 to 70 of about 1,013,866 (199)

Future Transboundary Water Stress and Its Drivers Under Climate Change: A Global Study

Earth's Future, 2020
Various transboundary river basins are facing increased pressure on water resources in near future. However, little is known ab out the future drivers globally, namely, changes in natural local runoff and natural inflows from upstream parts of a basin ...
Hafsa Ahmed Munia, Joseph H. A. Guillaume, Yoshihide Wada, Ted Veldkamp, Vili Virkki, Matti Kummu   +5 more
doaj   +1 more source

Dependence of Precipitation Scaling Patterns on Emission Scenarios for Representative Concentration Pathways

Journal of Climate, 2013
AbstractPattern scaling is an efficient way to generate projections of regional climate change for various emission scenarios. This approach assumes that the spatial pattern of changes per degree of global warming (scaling pattern) is the same among emission scenarios.
Yasuhiro Ishizaki, Hideo Shiogama, Seita Emori, Tokuta Yokohata, Toru Nozawa, Kiyoshi Takahashi, Tomoo Ogura, Masakazu Yoshimori, Tatsuya Nagashima   +8 more
openaire   +1 more source

Spatio-temporal analysis of temperature projections based on representative concentration pathways for Satluj River Basin, India

Cogent Engineering, 2021
A spatio-temporal analysis of representative concentration pathways (RCPs)-based projections of surface air temperatures under different combinations of global circulation models (GCMs) and RCPs for Satluj River Basin has been presented.
Mukesh Kumar Gupta, Mohammed Sharif
doaj   +1 more source

Zn(II)-curc targets p53 in thyroid cancer cells [PDF]

, 2015
P53 mutation is a common event in many cancers, including thyroid carcinoma. Defective p53 activity promotes cancer resistance to therapies and a more malignant phenotype, acquiring oncogenic functions.
Crispini, Alessandra, D'Orazi, Gabriella, D'Orazi, Valerio, Garufi, Alessia   +3 more
core   +2 more sources

Autophagy: A cyto-protective mechanism which prevents primary human hepatocyte apoptosis during oxidative stress [PDF]

, 2012
The role of autophagy in the response of human hepatocytes to oxidative stress remains unknown. Understanding this process may have important implications for the understanding of basic liver epithelial cell biology and the responses of hepatocytes ...
Biederbick A, Christopher J. Weston, David H. Adams, Munafo´ DB, Ricky H. Bhogal, Schroedl C, Simon C. Afford, Stuart M. Curbishley   +7 more
core   +1 more source

Climate Change Impacts on the Energy System of a Climate-Vulnerable Mediterranean Country (Greece)

Atmosphere
Climate change is expected to significantly affect countries in Southern Europe and the Mediterranean Basin, causing higher-than-average temperature increases, considerable reductions in rainfall and water runoff, and extreme events such as heatwaves ...
Elena Georgopoulou, Sevastianos Mirasgedis, Yannis Sarafidis, Christos Giannakopoulos, Konstantinos V. Varotsos, Nikos Gakis   +5 more
doaj   +1 more source

Future changes in extreme heatwaves in terms of intensity and duration over the CORDEX-East Asia Phase Two domain using multi-GCM and multi-RCM chains

Environmental Research Letters, 2023
An extreme heatwave, in terms of intensity and duration, is projected to occur at the end of the 21st century (2071–2100) over the whole of East Asia.
Young-Hyun Kim, Joong-Bae Ahn, Myoung-Seok Suh, Dong-Hyun Cha, Eun-Chul Chang, Seung-Ki Min, Young-Hwa Byun, Jin-Uk Kim   +7 more
doaj   +1 more source

Cooperation of Gq, Gi, and G12/13 in Protein Kinase D Activation and Phosphorylation Induced by Lysophosphatidic Acid [PDF]

, 2003
To examine the contribution of different G-protein pathways to lysophosphatidic acid (LPA)-induced protein kinase D (PKD) activation, we tested the effect of LPA on PKD activity in murine embryonic cell lines deficient in Galpha q/11 (Galpha q/11 KO ...
Gu, Jennifer, Rozengurt, Enrique, Slice, Lee W., Yuan, Jingzhen   +3 more
core  

Oncogenic K-Ras suppresses IP₃-dependent Ca²⁺ release through remodeling of IP₃Rs isoform composition and ER luminal Ca²⁺ levels in colorectal cancer cell lines [PDF]

, 2014
The GTPase Ras is a molecular switch engaged downstream of G-protein coupled receptors and receptor tyrosine inases that controls multiple cell fate-determining signalling athways.
Bootman, Martin D., Cook, Simon J., Foets, Thomas C. F., Pierro, Cristina, Roderick, H. Llewelyn   +4 more
core   +2 more sources

Nationwide projections of heat- and cold-related mortality impacts under various climate change and population development scenarios in Switzerland

Environmental Research Letters, 2023
Climate change and progressive population development (i.e., ageing and changes in population size) are altering the temporal patterns of temperature-related mortality in Switzerland.
Evan de Schrijver, Sidharth Sivaraj, Christoph C Raible, Oscar H Franco, Kai Chen, Ana M Vicedo-Cabrera   +5 more
doaj   +1 more source