Results 51 to 60 of about 1,933,509 (376)

Iterative Delegations in Liquid Democracy with Restricted Preferences

, 2019
In this paper, we study liquid democracy, a collective decision making paradigm which lies between direct and representative democracy. One main feature of liquid democracy is that voters can delegate their votes in a transitive manner so that: A ...
Escoffier, Bruno, Gilbert, Hugo, Pass-Lanneau, Adèle   +2 more
core   +2 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

The Politics of Democratizing Finance: A Radical View [PDF]

, 2019
How can finance be durably democratized? In the centers of financial power in both the United States and the United Kingdom, proposals now circulate to give workers and the public more say over how flows of credit are allocated.
McCarthy, Michael A.
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Information, Polarization and Delegation in Democracy [PDF]

This paper investigates the merits of different democratic institutions when politics is uni-dimensional, there is uncertainty both about the preferences of the future electorate and the future polarization of political parties, and politicians have ...
Christian Schultz
core   +3 more sources

Deepening democracy within Ireland's social partnership [PDF]

, 2009
Ireland's social partnership process, now under attack from a number of quarters, has repeatedly been charged with being 'undemocratic' in that it undermines the sovereign position of elected political representatives, with key policy formulation and ...
Allen K., Bang H. P., Benhabib S., Berlin I., Bogason P., Castells M., Cornwall A., Dean M., Fung A., Government of Ireland, Habermas J., Hastings T., Held D., Held D., Hirst P., Hulme D., Kirby P., Kooiman J., Lewis D., Macpherson C. B., Mansbridge J., March J. G., MEJN, Mouffe C., Murphy G., Murphy M., NESC, National Economic and Social Council, Newman J., Niamh Gaynor, Pearce J., Pierre J., Reddel T., Rosell S. A., Sørensen E., Tansey S. D., The Irish Times, Triantafillou P., Weber H., Ó Cinnéide S., Ó Cinnéide S.   +39 more
core   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

REPRESENTATIVE DEMOCRACY IN FEDERAL CITY

RUDN Journal of Public Administration, 2016
The article analyzes the quantitative representation of citizens in the representative bodies of state power and local self-government in cities of federal significance.
Nina N Musinova
doaj  

Populism and Technocracy: Pillars of Postwar Representative Democracy in Europe

Perspective Politice
The established representative democracy in Europe is facing growing challenges. In a rapidly evolving landscape that resolves some crises while encountering new ones, two movements – populism and technocracy – are emerging as alternatives to the ...
Rareș-Bogdan ROȘULESCU
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source