Results 51 to 60 of about 1,870,391 (376)

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

Molecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček   +14 more
wiley   +1 more source

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source

Mauro Dorato, Science and Representative Democracy: Experts and Citizens, Bloomsbury Academic, 2023, 200pp., £85.00 (hbk), ISBN 9781350277724. [PDF]

Manuscrito
Mauro Dorato's "Science and Representative Democracy" argues for the essential link between science and democracy. He posits both as problem-solving systems, advocating for representative democracy to integrate scientific knowledge into policy and ...
BRUNO BORGE
doaj   +1 more source

Review of Handbook of Direct Democracy in Central and Eastern Europe after 1989

Проблеми на постмодерността, 2022
In the modern world, democracy is a dominant form of rule. Different societies are implementing both indirect and direct democracy. Various factors define the level of realization of one of the two.
Miroslav Terziyski
doaj   +1 more source

Is the Internet a Viable Threat to Representative Democracy? [PDF]

, 2008
The Internet, despite its relatively recent advent, is critical to millions of Americans’ way of life. Although the Internet arguably opens new opportunities for citizens to become more directly involved in their government, some scholars fear this ...
Thompson, David M.
core   +1 more source

Explaining Institutional Change: Why Elected Politicians Implement Direct Democracy [PDF]

, 2008
In existing models of direct democratic institutions, the median voter benefits, but representative politicians are harmed since their policy choices can be overridden.
Adam Przeworski, Alberto Diaz-Cayeros, Alex Cukierman, Anke S Kessler, Avner Greif, Barbara Geddes, Carles Boix, Carles Boix, Christine A Kelleher, Daniel A Smith, Daniel A Smith, Daniel A Smith, Daron Acemoglu, Daron Acemoglu, David Hugh-Jones, David S Broder, Douglass C North, Elisabeth R Gerber, Elisabeth R Gerber, Elizabeth Garrett, Eric Maskin, Frederick J Boehmke, George H Haynes, Gian Milesi-Ferretti, Hanson, In-Koo Cho, Jeff S Banks, John G Matsusaka, John G Matsusaka, John M Allswang, Kathleen Bawn, Keith E Hamm, Kenneth Benoit, Matthew D Mccubbins, Nolan M Mccarty, O&apos, Patrick Dunleavy, Paul T David, Peter Schrag, Ronald Rogowski, Rui J P Figueiredo, Shaun Bowler, Shaun Bowler, Shaun Bowler, Stein Rokkan, Steven L Piott, Susan E Scarrow, Thomas Goebel, Thomas Romer, Timothy J Besley, Valentina A Bali, William H Riker   +51 more
core   +2 more sources

Comprehensive profiling of lncRNAs and mRNAs enriched in small extracellular vesicles for early noninvasive detection of colorectal cancer: diagnostic panel assembly and extensive validation

Molecular Oncology, EarlyView.
Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova, Marketa Pavlikova, Lucie Pifkova, Robin Jugas, Tana Machackova, Lenka Radova, Milana Sachlova, Renata Bartosova, Tetiana Samoilenko, Zuzana Feckova, Jana Orlickova, Erika Slamova, Elleni Ponechal Michu, Dagmar Al Tukmachi, Michaela Ruckova, Martina Vodinska, Jan Kotoucek, Tina Catela Ivkovic, Marie Boudna, Lucia Bohovicova, Teodor Stanek, Jana Halamkova, Martin Svoboda, Vladimir Prochazka, Tomas Grolich, Zdenek Kala, Ondrej Slaby   +26 more
wiley   +1 more source

The Impact of Referendums on the Centralisation of Public Goods Provision: A Political Economy Approach [PDF]

The paper compares decision-making on the centralisation of public goods provision in the presence of regional externalities under representative and direct democratic institutions.
Christoph A. Schaltegger, Jan Schnellenbach, Lars P. Feld   +2 more
core   +3 more sources

Contemporary Forms of Representative Democracy

Anali Hrvatskog Politološkog Društva, 2007
In this paper, the author examines contemporary forms of representative democracy in the light of three theoretical and ideological conflicts. The first conflict concerns those who strive for a consolidated representative democracy, and develop theories ...
Klaus von Beyme
doaj  

Authoritarian Liberalism in Contemporary Europe: methodological approaches and conceptual models

Politics in Central Europe, 2019
The author conducts a comparative analysis of authoritarian liberalism’s concepts in contemporary political theory. The paper deals with the main directions of interpretation of authoritarian liberalism in the framework of methodological approaches and ...
Popov Maxim
doaj   +1 more source