Results 281 to 290 of about 2,422,307 (349)

A Delphi Study to Identify Priority Indicators for Formulary Selection of Innovative Anticancer Drugs in China. [PDF]

Health Expect
Zhao J, Hu Y, Zhu Y, Wu B, Hu M, Li M, Liang Y, Li J, Qiao G, Fan X, Yan H, Wang X, Zheng Z, Zhang X, Li J, Lou T, Ma Y.   +16 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Microbial Diversity of the Baikal Rift Zone Freshwater Alkaline Hot Springs and the Ecology of Polyextremophilic Dissimilatory Iron-Reducing Bacteria. [PDF]

Biology (Basel)
Maltseva AI, Elcheninov AG, Klyukina AA, Gololobova AV, Lavrentyeva EV, Banzaraktsaeva TG, Dambaev VB, Barkhutova DD, Zavarzina DG, Frolov EN.   +9 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Genetic genealogy of the Piast dynasty and related European royal families. [PDF]

Nat Commun
Zenczak M, Handschuh L, Marcinkowska-Swojak M, Stolarek I, Golubiński M, Juras A, Trzciński D, Chyleński M, Dębski A, Losik A, Jasiński T, Wrzesińska A, Matla M, Kóčka-Krenz H, Legocki AB, Dobosz J, Figlerowicz M.   +16 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Grappling with the democratic transition: parliamentary accountability and the House of Representatives of Zanzibar, Tanzania

, 2013
Aley Soud Nassor
openalex   +1 more source

Metagenomic-scale analysis of the predicted protein structure universe

Steinegger M, Yeo J, Han Y, Bordin N, Lau A, Kandathil S, Kim H, Karin EL, Mirdita M, Jones D, Orengo C.   +10 more
europepmc   +1 more source

Urologists’ Views on Contact With Industry Representatives: A Pilot Survey

, 2017
Marc Zeffren, Joel Hillelsohn, Michael Stern   +2 more
openalex   +1 more source

Policy barriers to drug repurposing in Europe: different stakeholder perspectives identified during survey-based shortlisting of key challenges. [PDF]

Health Policy Open
Gyöngyösi K, Petykó ZI, Hosszú D, Pantziarka P, van der Meer HG, Lo DC, Csanádi M, Obeng GD, Kaló Z, Inotai A.   +9 more
europepmc   +1 more source