Results 241 to 250 of about 409,457 (308)

Crosstalk Between CTSB+ Glioblastoma Cells and S100A10+ Macrophages: A Self‐Reinforcing Circuit Promotes Immune Evasion and Limits Response to Immunotherapy

Advanced Science, EarlyView.
In glioblastoma, M2‐polarized macrophages secrete IL‐6, which activates STAT3 signaling in tumor cells to upregulate CTSB. Tumor‐derived CTSB binds the C‐terminus of macrophage S100A10, reinforcing M2 polarization and further IL‐6 secretion, thereby establishing a feedforward IL‐6/STAT3/CTSB/S100A10 loop. This cascade drives tumor growth, invasion, and
Hao Zhang, Nan Zhang, Xisong Liang, Jie Wen, Ziyu Dai, Wantao Wu, Shuyu Li, Songshan Feng, Zaoqu Liu, Zhiwei Xia, Peng Luo, Quan Cheng   +11 more
wiley   +1 more source

USP5 Stabilizes TGFBR1 to Drive Vascular Smooth Muscle Cell Senescence and Atherosclerosis

Advanced Science, EarlyView.
This study reveals that USP5 drives vascular smooth muscle cell senescence and atherosclerosis by stabilizing TGFBR1, suppressing IDH2, and promoting glycolytic reprogramming, identifying the USP5‐TGFBR1‐IDH2 axis as a potential therapeutic target. ABSTRACT Vascular smooth muscle cell (VSMC) senescence contributes importantly to atherosclerotic plaque ...
Xinhai Cui, Yuanlong Hu, Lin Lin, Lei Zhang, Chao Li, Yunlun Li   +5 more
wiley   +1 more source

Evolution of Epigenetic Regulation in Plant Reproduction. [PDF]

Epigenomes
Brukhin V.
europepmc   +1 more source

miR-29b as an Anti-Fibrotic Therapeutic: Mechanisms, Disease Biology and Translational Opportunities. [PDF]

Cells
Armstrong L, McKenna DJ, Mihalovova E, Gribben RD, Roodnat AW, Callan B, Willoughby CE.   +6 more
europepmc   +1 more source

Colony politics to chemical warfare: phenotypic plasticity in Streptomyces. [PDF]

Essays Biochem
Munnoch JT, Hoskisson PA.
europepmc   +1 more source

Expanding perspectives on specialized metabolism in Streptomyces bacteria. [PDF]

Essays Biochem
Tiller LA, McCoy Bridges KP, Hindra, Elliot MA.   +3 more
europepmc   +1 more source

PML-driven sumoylation of PML::RARA-bound repressors drives hematopoietic progenitor immortalization. [PDF]

J Exp Med
Wu HC, Laplantine E, Esnault C, Niwa-Kawakita M, Zhang Y, De Almeida Bastos V, Geoffroy MC, de Thé H.   +7 more
europepmc   +1 more source

LINE-1 Retrotransposons and Amyotrophic Lateral Sclerosis. [PDF]

Int J Mol Sci
Korošec T, Rogelj B, Župunski V.
europepmc   +1 more source