Results 11 to 20 of about 297,096 (313)

Estrogen represses gene expression through reconfiguring chromatin structures [PDF]

Nucleic Acids Research, 2013
Estrogen regulates over a thousand genes, with an equal number of them being induced or repressed. The distinct mechanisms underlying these dual transcriptional effects remain largely unknown. We derived comprehensive views of the transcription machineries assembled at estrogen-responsive genes through integrating multiple types of genomic data. In the
Osmanbeyoglu, Hatice Ulku, Lu, Kevin N., Oesterreich, Steffi, Day, Roger S., Benos, Panayiotis V., Coronnello, Claudia, Lu, Xinghua   +6 more
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Structural mechanism of HP1α-dependent transcriptional repression and chromatin compaction

Structure, 2023
AbstractHeterochromatin protein 1 (HP1) plays a central role in establishing and maintaining constitutive heterochromatin. However, the mechanisms underlying HP1-nucleosome interactions and their contributions to heterochromatin functions remain elusive.
Vladyslava Sokolova, Jacob Miratsky, Vladimir Svetlov, Michael Brenowitz, John Vant, Tyler S. Lewis, Kelly Dryden, Gahyun Lee, Shayan Sarkar, Evgeny Nudler, Abhishek Singharoy, Dongyan Tan   +11 more
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Repression of IS200 transposase synthesis by RNA secondary structures [PDF]

Nucleic Acids Research, 1999
The IS 200 transposase, a 16 kDa polypeptide encoded by the single open reading frame (ORF) of the insertion element, has been identified using an expression system based on T7 RNA polymerase. In wild-type IS 200, two sets of internal inverted repeats that generate RNA secondary structures provide two independent mechanisms for repression of ...
Beuzón López, Carmen del Rosario, Marqués, Silvia, Casadesús Pursals, Josep   +2 more
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Structural insight into glucose repression of the mannitol operon [PDF]

Scientific Reports, 2019
AbstractCarbon catabolite repression is a regulatory mechanism to ensure sequential utilization of carbohydrates and is usually accomplished by repression of genes for the transport and metabolism of less preferred carbon compounds by a more preferred one.
Mangyu Choe, Huitae Min, Young-Ha Park, Yeon-Ran Kim, Jae-Sung Woo, Yeong-Jae Seok   +5 more
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Structure, mechanism, and regulation of polycomb-repressive complex 2 [PDF]

Journal of Biological Chemistry, 2018
Polycomb repressive complex 2 (PRC2) methylates lysine 27 in histone H3, a modification associated with epigenetic gene silencing. This complex plays a fundamental role in regulating cellular differentiation and development, and PRC2 overexpression and mutations have been implicated in numerous cancers.
Lindsay E, Moritz, Raymond C, Trievel
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Canstatin represses glioma growth by inhibiting formation of VM-like structures [PDF]

Translational Neuroscience, 2021
Abstract Vasculogenic mimicry (VM) is different from classical tumor angiogenesis and does not depend on endothelial cells. VM is closely related to the prognosis of various cancers. Canstatin was first identified as an endogenous angiogenesis inhibitor.
Ma Yuqiang, Wu Tao, Zhou Houjie, He Guilu, Li Yifei, Wang Bocheng, Guo Qiang, Chen Baodong, Li Weiping   +8 more
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RGS12TS-S Localizes at Nuclear Matrix-Associated Subnuclear Structures and Represses Transcription: Structural Requirements for Subnuclear Targeting and Transcriptional Repression [PDF]

Molecular and Cellular Biology, 2002
RGS12TS-S, an 1,157-amino-acid RGS protein (regulator of G protein signaling), is a nuclear protein that exhibits a unique pattern of subnuclear organization into nuclear foci or dots when expressed endogenously or ectopically. We now report that RGS12TS-S is a nuclear matrix protein and identify structural determinants that target this protein to the ...
Tapan K, Chatterjee, Rory A, Fisher
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Structure of the Transcriptionally Repressed Phosphate-Repressible Acid Phosphatase Gene (PHO5) of Saccharomyces cerevisiae [PDF]

Molecular and Cellular Biology, 1986
We developed a high-copy-number plasmid system containing the entire structural and regulatory sequences of the phosphate-repressible acid phosphatase (PHO5) gene and the TRP1/ARS1 replicator sequences of the yeast Saccharomyces cerevisiae to investigate the mechanism of repression-derepression of transcription.
L W, Bergman, M C, Stranathan, L H, Preis   +2 more
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Structural basis of RNA polymerase III transcription repression by Maf1 [PDF]

Nature Structural & Molecular Biology, 2019
ABSTRACTMaf1 is a highly conserved central regulator of transcription by RNA polymerase III (Pol III), and Maf1 activity influences a wide range of phenotypes from metabolic efficiency to lifespan. Here, we present a 3.3 Å cryo-EM structure of yeast Maf1 bound to Pol III, which establishes how Maf1 achieves transcription repression.
Vorländer, Matthias K., Baudin, Florence, Moir, Robyn D., Wetzel, René, Hagen, Wim J. H., Willis, Ian M., Müller, Christoph W.   +6 more
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Chromatin structure of transcriptionally competent and repressed genes. [PDF]

The EMBO Journal, 1990
We have compared transcriptionally competent and repressed genes with respect to their linker histone content and their ability to fold into higher-order structures. Histones were cross-linked covalently to DNA in chicken erythrocyte and oviduct nuclei by UV irradiation, and the DNA that was immunoprecipitated with anti-H1 and (for erythrocytes) anti ...
R T, Kamakaka, J O, Thomas
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