Results 61 to 70 of about 297,096 (313)

Structure theorems and the dynamics of nitrogen catabolite repression in yeast [PDF]

Proceedings of the National Academy of Sciences, 2005
By using current biological understanding, a conceptually simple, but mathematically complex, model is proposed for the dynamics of the gene circuit responsible for regulating nitrogen catabolite repression (NCR) in yeast. A variety of mathematical “structure” theorems are described that allow one to determine the asymptotic dynamics of complicated ...
Erik M, Boczko, Terrance G, Cooper, Tomas, Gedeon, Konstantin, Mischaikow, Deborah G, Murdock, Siddharth, Pratap, K Sam, Wells   +6 more
openaire   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The tax-inducible actin-bundling protein fascin is crucial for release and cell-to-cell transmission of human T-cell leukemia virus type 1 (HTLV-1) [PDF]

, 2016
The delta-retrovirus Human T-cell leukemia virus type 1 (HTLV-1) preferentially infects CD4(+) T-cells via cell-to-cell transmission. Viruses are transmitted by polarized budding and by transfer of viral biofilms at the virological synapse (VS ...
Gettemans, Jan, Gross, Christine, Kalmer, Martina, Millen, Sebastian, Thoma-Kress, Andrea K, Wiesmann, Veit, Wittenberg, Thomas   +6 more
core   +10 more sources

A gene-rich, transcriptionally active environment and the pre-deposition of repressive marks are predictive of susceptibility to KRAB/KAP1-mediated silencing

BMC Genomics, 2011
Background KRAB-ZFPs (Krüppel-associated box domain-zinc finger proteins) are vertebrate-restricted transcriptional repressors encoded in the hundreds by the mouse and human genomes.
Zangger Nadine, Quenneville Simon, Malani Nirav, Ambrosini Giovanna, Groner Anna C, Meylan Sylvain, Kapopoulou Adamandia, Kauzlaric Annamaria, Rougemont Jacques, Ciuffi Angela, Bushman Frederic D, Bucher Philipp, Trono Didier   +12 more
doaj   +1 more source

Structural Analyses of CrtJ and Its B₁₂-Binding Co-Regulators SAerR and LAerR from the Purple Photosynthetic Bacterium Rhodobacter capsulatus

Microorganisms, 2022
Among purple photosynthetic bacteria, the transcription factor CrtJ is a major regulator of photosystem gene expression. Depending on growing conditions, CrtJ can function as an aerobic repressor or an anaerobic activator of photosystem genes.
Vladimira Dragnea, Giovanni Gonzalez-Gutierrez, Carl E. Bauer   +2 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54.

PLoS Biology, 2006
RNA interference is triggered by double-stranded RNA that is processed into small interfering RNAs (siRNAs) by Dicer enzyme. Endogenously, RNA interference triggers are created from small noncoding RNAs called microRNAs (miRNAs).
Chia-ying Chu, Tariq M Rana
doaj   +1 more source

Moderation through exclusion? The journey of the Tunisian Ennahda from fundamentalist to conservative party [PDF]

, 2013
The success of processes of democratic change is often predicated on the moderation of anti-systemic and extremist parties. The literature on such parties argues that such moderation, namely the acceptance of democratic procedures, human rights, and a ...
Cavatorta, Francesco, Merone, Fabio
core   +2 more sources

Decoding Hairpin Structure Stability in Lin28-mediated Repression

Biochemistry
Lin28 protein is well-known for its role in inhibiting biogenesis of micro-RNAs (miRNAs) that belong to the let-7 family. The Lin28 and let-7 axis is associated with several types of cancer. It is imperative to understand the underlying mechanism to treat these cancer in a more efficient way.
Qiang Zhu, Limu Hu, Chang Cui, Min Zang, Hao Dong, Jing Ma   +5 more
openaire   +2 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source