Temporal and Cell‐Specific Regulation of Synaptic Homeostasis by the Chromatin Remodeler Chd1
Chd1, the Drosophila homologue of mammalian CHD2 ‐ a gene linked to autism, epilepsy, and intellectual disability, is required for synaptic homeostatic plasticity. Chd1 in glia is necessary for the rapid induction of synaptic homeostasis, whereas Chd1 in motoneurons, muscle, and glia is critical for long‐term maintenance.
Danielle T. Morency +19 more
wiley +1 more source
Celebrating 120 years since the birth of Nise da Silveira: a legacy of humanization of psychiatry. [PDF]
Dutra PEP, Nardi AE.
europepmc +1 more source
RETREG1‐Mediated Reticulophagy is Essential for Dendritic Cell Maturation and Function in Sepsis
Reticulophagy regulator 1 (RETREG1) maintains dendritic cell (DC) maturation and function in early sepsis. Mechanistically, activating transcription factor 6 (ATF6) acts as a direct transcription factor regulating RETREG1 expression in response to sepsis‐induced endoplasmic reticulum (ER) stress.
Ren‐Qi Yao +28 more
wiley +1 more source
How cells tame noise while maintaining ultrasensitive transcriptional responses. [PDF]
Jeong EM, Chung CY, Kim JK.
europepmc +1 more source
Hypoxia-Ischemia Induced Age-Dependent Gene Transcription Effects at Two Development Stages in the Neonate Mouse Brain. [PDF]
Dupré N +8 more
europepmc +1 more source
Editorial: Migrants' psychosocial health: cultural and religious resources through resilience and coping. [PDF]
Cetrez ÖA, Kaynak S.
europepmc +1 more source
Versatile CRISPR‐Cas Tools for Gene Regulation in Zebrafish via an Enhanced Q Binary System
This study introduces CRISPR‐Q, a transgenic CRISPR‐Cas system leveraging the QFvpr/QUAS binary expression platform in zebrafish. CRISPR‐Q overcomes previous challenges in achieving stable and efficient gene regulation. By enabling precise spatiotemporal control of transcript knockdown (CRISPR‐QKD) and gene activation (CRISPR‐Qa), it provides a ...
Miaoyuan Shi +13 more
wiley +1 more source
A tool for modeling gene regulatory networks (GRN_modeler) and its applications to synthetic biology. [PDF]
Holló G, Park JH, Boni E, Schaerli Y.
europepmc +1 more source

