Results 121 to 130 of about 308,170 (360)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Terrorism and the Constitutional Order [PDF]

, 2006
We panicked the last time terrorists struck, and we will panic the next time. September 11 was merely a pinprick compared to the devastation of a suitcase A-bomb or an anthrax epidemic.
Ackerman, Bruce
core   +2 more sources

Dynamics of activating and repressive histone modifications in Drosophila neural stem cell lineages and brain tumors [PDF]

, 2019
Merve Deniz Abdusselamoglu, Lisa Landskron, Sarah Bowman, Elif Eroğlu, Thomas R. Burkard, Robert E. Kingston, Juergen A. Knoblich   +6 more
openalex   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Molecular Regulation of the Polycomb Repressive-Deubiquitinase [PDF]

, 2020
Cameron J. Reddington, Matthias Fellner, Abigail E. Burgess, Peter D. Mace   +3 more
openalex   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Sobre la implementación de la limpieza política franquista en Navarra en 1936-1937

Diacronie. Studi di Storia Contemporanea, 2019
This article delves into the characteristics of the Franquist political cleansing implemented in Navarre, the Spanish province where in relative terms, it was the strongest.
Fernando Mikelarena
doaj  

Discourses on Violence in Costa Rica, El Salvador, and Nicaragua: Youth, Crime, and the Responses of the State [PDF]

The paper analyzes the social construction of youth violence in Nicaragua, Costa Rica, and El Salvador on the one hand, and the related security policies of the three states, on the other.
Peter Peetz
core  

Drosophila Single-minded Represses Gene Transcription by Activating the Expression of Repressive Factors

, 2021
Jack T. Mosher, Patricia A. Estes, Stephen T. Crews   +2 more
openalex   +1 more source

A Stochastic Model of the Repressive-Preventive Impact on Crime: from Intuition to Calculations [PDF]

, 2021
S. V. Maksimov, Yury Vasin, Kanat Utarov
openalex   +1 more source