Results 101 to 110 of about 30,544 (313)

R-loops associated with triplet repeat expansions promote gene silencing in Friedreich ataxia and fragile X syndrome.

PLoS Genetics, 2014
Friedreich ataxia (FRDA) and Fragile X syndrome (FXS) are among 40 diseases associated with expansion of repeated sequences (TREDs). Although their molecular pathology is not well understood, formation of repressive chromatin and unusual DNA structures ...
Matthias Groh, Michele M P Lufino, Richard Wade-Martins, Natalia Gromak   +3 more
doaj   +1 more source

KGB against former political prisoners and deportees

Genocidas ir Rezistencija, 2008
The Soviet totalitarian regime sought to crush and destroy the real and potential enemies of the new regime through mass repression in Lithuania between 1940 and 1953.
Kristina Burinskaitė
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Simulated chromatin structures reproduce findings from super-resolution microscopy experiments.

, 2019
(A) Characteristic histone modification profiles for repressive, active and inactive chromatin. (B) The sizes of repressive (blue), active (orange) and inactive (green) chromatin domains, as measured by their radiuses of gyration, are plotted as a ...
Yifeng Qi (6817691), Bin Zhang (64682)
core   +1 more source

Polycomb Repressive Complex 2 Controls the Embryo-to-Seedling Phase Transition [PDF]

, 2011
Polycomb repressive complex 2 (PRC2) is a key regulator of epigenetic states catalyzing histone H3 lysine 27 trimethylation (H3K27me3), a repressive chromatin mark.
M. Heese, Paul E. Grini, Daniel Bouyer, P.E. Grini, Andersen, Ellen, Moritz K. Nowack, Roudier, Francois, Renou, Jean-Pierre,, A. Schnittger, Andersen, Ellen D., J.P. Renou, Jean-Pierre Renou, Grini, Paul E., Ellen D. Andersen, Grini, Paul E, Nowack, Moritz, Vincent Colot, M.K. Nowack, Maren Heese, Paul E Grini, Colot, Vincent, D. Gey, Ellen D Andersen, Arp Schnittger, Renou, Jean-Pierre, J.-P., D. Bouyer, Nowack, Moritz K., Goodrich, Justin, Schnittger, Arp, Delphine Gey, Heese, Maren, Francois Roudier, Andersen, Ellen D, Gey, Delphine, Moritz K Nowack, Grini, Paul, J. Goodrich, Renou, Jean-Pierre, Bouyer, Daniel, E.D. Andersen, F. Roudier, V. Colot, Justin Goodrich   +42 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Repression and Protest. Structural Models and Strategic Interactions

, 2011
Les printemps arabes ont remis sur le devant de la scène une vieille interrogation des théories de l’action collective : la répression stimule-t-elle ou annihile-t-elle la mobilisation ? Cet article se propose de dresser un bilan des savoirs sur la question et, au-delà, de proposer quelques pistes de recherche afin de dépasser certaines apories ...
Combes, Hélène, Fillieule, Olivier
openaire   +4 more sources

SUMO pathway dependent recruitment of cellular repressors to herpes simplex virus type 1 genomes [PDF]

, 2011
Components of promyelocytic leukaemia (PML) nuclear bodies (ND10) are recruited to sites associated with herpes simplex virus type 1 (HSV-1) genomes soon after they enter the nucleus. This cellular response is linked to intrinsic antiviral resistance and
Delphine Cuchet-Lourenço, Roger D Everett, Boutell Chris, Roger D. Everett, Sykes Amanda, Murray Jill, Kyle Grant, Jill Murray, Cuchet-Lourenço Delphine, Chris Boutell, Sykes, A., Cuchet-Lourenço, D., Orr Anne, Grant, K., Everett, R.D., Grant Kyle, Boutell, C., Anne Orr, Amanda Sykes, Lukashchuk, V., Murray, J., Vera Lukashchuk, Everett Roger D., Lukashchuk Vera, Orr, A.   +24 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Análisis bioinformático de los reguladores epigenéticos [PDF]

, 2012
[spa] En la siguiente tesis se presentan tres estudios centrados en diferentes aspectos estructurales y funcionales de los dominios efectores presentes en los reguladores epigenéticos y sus consecuencias para la interpretación biológica de las ...
Lois Olmo, Sergio
core