Results 111 to 120 of about 30,587 (268)

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Internet Shutdowns in Africa| Dissent Does Not Die in Darkness: Network Shutdowns and Collective Action in African Countries

International Journal of Communication, 2020
Research on the role of communication technology in repression and collective action focuses largely on social movements in the West or the Arab Spring.
Jan Rydzak, Moses Karanja, Nicholas Opiyo   +2 more
doaj  

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Small molecules and heat treatments reverse vernalization via epigenetic modification in Arabidopsis

Communications Biology
Monocarpic plants flower only once and then produce seeds. Many monocarpic plants require a cold treatment known as vernalization before they flower. This requirement delays flowering until the plant senses warm temperatures in the spring.
Nana Otsuka, Ryoya Yamaguchi, Hikaru Sawa, Naoya Kadofusa, Nanako Kato, Yasuyuki Nomura, Nobutoshi Yamaguchi, Atsushi J. Nagano, Ayato Sato, Makoto Shirakawa, Toshiro Ito   +10 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Repression and Protest. Structural Models and Strategic Interactions

, 2011
Les printemps arabes ont remis sur le devant de la scène une vieille interrogation des théories de l’action collective : la répression stimule-t-elle ou annihile-t-elle la mobilisation ? Cet article se propose de dresser un bilan des savoirs sur la question et, au-delà, de proposer quelques pistes de recherche afin de dépasser certaines apories ...
Combes, Hélène, Fillieule, Olivier
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

MODERN GERMAN HISTORIOGRAPHY ON THE MECHANISM FOR CONTROL AND SUPPRESSION OF THE NAZI STATE: GESTAPO AND NAZI CONCENTRATION CAMPS

Вестник Кемеровского государственного университета, 2014
The paper describes the process of the 1990s deployment of German historians’ works to analyse the repressive structures of the Third Reich on the basis of regional and European sources. The major trends and research methodology are analyzed in the paper.
L. N. Korneva
doaj  

A COMMEMORATION OF WOUNDS ENDURED: WRITING AS RESISTANCE IN MARGARET ATWOOD’S THE BLIND ASSASSIN

Filolog
Margaret Atwood’s The Blind Assassin depicts repressive patriarchal practices such as insistence upon the cult of Victorian womanhood and the sacrificial angel trope imposed on women in 1930s and 1940s Canada.
Marija N. Gagić
doaj   +1 more source