Results 71 to 80 of about 30,587 (268)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Reprisal Actions of Partisans in Kaunas County (1944–1952), Part 1
Genocidas ir Rezistencija, 2019 This research focuses on the punitive operations of Lithuanian partisans in Kaunas County. The data covers the voloks that belonged to Kaunas County before the administrative-territorial reform of 1946, after which the territory of the county changed ...
Gintautas Miknevičius
doaj +1 more source
A molecular switch regulating transcriptional repression and activation of PPARγ
Nature Communications, 2020 Structural studies of nuclear receptor transcription factors revealed that nearly all nuclear receptors share a conserved helix 12 dependent transcriptional activation mechanism.
Jinsai Shang +8 more
doaj +1 more source
Social and cultural activities of the university [PDF]
Sociološki Pregled, 2001 The paper deals with the meaning of university and its value (achievement of value) in a society, so, according to that, as with a specific aspect of culture.
Božović Ratko
doaj +1 more source
The influence of repressive legislation on the structure of a social media network [PDF]
EPL (Europhysics Letters), 2013 4 pages, 4 figures, submitted to ...
Marianne Marcoux, David Lusseau
openaire +3 more sources
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
KGB against former political prisoners and deportees
Genocidas ir Rezistencija, 2008 The Soviet totalitarian regime sought to crush and destroy the real and potential enemies of the new regime through mass repression in Lithuania between 1940 and 1953.
Kristina Burinskaitė
doaj +1 more source