Results 151 to 160 of about 334,121 (353)
Advanced Functional Materials, EarlyView.Oct4‐nanoscript, a biomimetic nanoparticle‐based artificial transcription factor, precisely regulates cellular rejuvenation by activating Oct4 target genes, restoring epigenetic marks, and reducing DNA damage. In a progeria model, it effectively rescued aging‐associated pathologies and extended lifespan.
Hongwon Kim +8 more
wiley +1 more source
A Master equation approach to modeling an artificial protein motor
, 2010 Linear bio-molecular motors move unidirectionally along a track by coordinating several different processes, such as fuel (ATP) capture, hydrolysis, conformational changes, binding and unbinding from a track, and center-of-mass diffusion.
Alberts +35 more
core +1 more source
Repressor-minus and operator-constitutive de-repressed mutants of F-like R factors: their effect on chromosomal transfer by HfrC [PDF]
, 1969 Elinor Meynell, Marylyn Cooke
openalex +1 more source
Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting
Advanced Materials, EarlyView.CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu +4 more
wiley +1 more source
مجله علوم روانشناختی, 2016 Excessive inhibition of emotions is associated with a variety of psychological and health problems. Weinberger developed an inventory to assess socio-emotional adjustment.
Zoha Saeedi +2 more
doaj
Permanent Plasma Surface Functionalization of Internal Surface Areas
Advanced Materials Interfaces, EarlyView.With applications in various fields including biomedical sciences, textiles, or filter industry, stable functionalization of porous membranes is indispensable. Plasma‐activated species with specific reactivities infiltrate porous substrates at different penetration depths due to their distinct energies and diffusivities.
Dirk Hegemann +4 more
wiley +1 more source
The role of the regulator-gene product (repressor) in catabolite repression of β-galactosidase synthesis in Escherichia coli [PDF]
, 1968 J. Palmer, V. Moses
openalex +1 more source
Advanced Science, EarlyView.The study deciphers the landscapes of lineage‐related transcription factors in prostatic adenocarcinoma and neuroendocrine prostate cancer using an innovative approach. These findings, validated across cohorts, highlight TFs' roles in cell development and offer novel therapeutic targets.
Yu Wang +20 more
wiley +1 more source
Inhalable Hsa‐miR‐30a‐3p Liposomes Attenuate Pulmonary Fibrosis
Advanced Science, EarlyView.The study explores inhalable hsa‐miR‐30a‐3p‐loaded liposomes as a treatment for bleomycin‐induced pulmonary fibrosis in mice. Hsa‐miR‐30a‐3p is electroporated into liposomes and formulated into a dry powder for inhalation. Delivered via dry powder inhalation, it improves pulmonary function, promotes myofibroblast de‐differentiation by targeting CNPY2 ...
Shuo Liu +14 more
wiley +1 more source
Competitive binding of Activator-Repressor in Stochastic Gene Expression [PDF]
arXivRegulation of gene expression is the consequence of interactions between the promoter of the gene and the transcription factors (TFs). In this paper, we explore the features of a genetic network where the TFs (activators and repressors) bind the promoter in a competitive way. We develop an analytical theory that offers detailed reaction kinetics of the
arxiv