Results 181 to 190 of about 2,089,944 (391)
The Recent Inventions for Reproducing the Sound of the Human Voice [PDF]
, 1878 Shelford Bidwell
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Molecular Oncology, EarlyView.Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho +11 more
wiley +1 more source
On a Method of reproducing Astronomical Photographs [PDF]
, 1897 K. D. Naegamvala
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Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
THE REPRODUCIBILITY OF THE CADMIUM ELECTRODE. [PDF]
, 1915 Frederick H. Getman, Vernette L. Gibbons
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A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
1,500 scientists lift the lid on reproducibility
Nature, 2016 M. Baker
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Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald +18 more
wiley +1 more source
A new type of lamp and reflector for I.R. simulation [PDF]
The lamps and reflectors used for infrared radiation simulation tests at ESTEC did not allow researchers to predict the intensity needed for test conditions with the desired accuracy.
Saenger, G.
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An Apparatus for Reproducing at Pleasure an Invariable Quantity of Electricity [PDF]
, 1886 Maxim Deprez
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