Results 41 to 50 of about 1,729,850 (302)

Reproducibility of extracellular vesicle research.

European Journal of Cell Biology, 2022
Cells release membrane-delimited particles into the environment. These particles are called "extracellular vesicles" (EVs), and EVs are present in fluids contacting cells, including body fluids and conditioned culture media.
R. Nieuwland, P. Siljander, J. Falcón-Perez, Kenneth W. Witwer   +3 more
semanticscholar   +1 more source

Realising Open Data Principles In UK Research Institutions

International Journal of Digital Curation
We report on the state of open research data (ORD) policy and practice across UK research institutions through the STAR (Sustainable & TrAnsparent Research data) project. Through qualitative interviews, focus groups, and workshops involving 52 university
Pen-Yuan Hsing, Jessica Wheeler, Lorna Duncan, Rosalind Strang, Neil Jacobs   +4 more
doaj   +1 more source

Convolutional Neural Network Addresses the Confounding Impact of CT Reconstruction Kernels on Radiomics Studies

Tomography, 2021
Achieving high feature reproducibility while preserving biological information is one of the main challenges for the generalizability of current radiomics studies.
Jin H. Yoon, Shawn H. Sun, Manjun Xiao, Hao Yang, Lin Lu, Yajun Li, Lawrence H. Schwartz, Binsheng Zhao   +7 more
doaj   +1 more source

Cellular extrusion bioprinting improves kidney organoid reproducibility and conformation.

Nature Materials, 2020
Directed differentiation of human pluripotent stem cells to kidney organoids brings the prospect of drug screening, disease modelling and the generation of tissue for renal replacement.
K. Lawlor, J. Vanslambrouck, J. W. Higgins, A. Chambon, Kristina Bishard, D. Arndt, Pei Xuan Er, Sean B. Wilson, S. Howden, K. S. Tan, Fanyi Li, Lorna J. Hale, B. Shepherd, S. Pentoney, S. Presnell, Alice E. Chen, M. Little   +16 more
semanticscholar   +1 more source

Using Mice to Model Human Disease: Understanding the Roles of Baseline Housing-Induced and Experimentally Imposed Stresses in Animal Welfare and Experimental Reproducibility

Animals, 2022
Mice are the most common animal used to study disease, but there are real concerns about the reproducibility of many of these experiments. This review discusses how several different sources of chronic stress can directly impact experimental outcomes ...
Bonnie L. Hylander, Elizabeth A. Repasky, Sandra Sexton   +2 more
doaj   +1 more source

Imaging of High‐Risk Neuroblastoma: Recommendations From SIOPEN Radiology and Nuclear Medicine Specialty Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Neuroblastoma is the most common extracranial solid tumor in early childhood. Its clinical behavior is highly variable, ranging from spontaneous regression to fatal outcome despite intensive treatment. The International Society of Pediatric Oncology Europe Neuroblastoma Group (SIOPEN) Radiology and Nuclear Medicine Specialty Committees ...
Annemieke Littooij, Catia Olianti, Herve Brisse, Pier Luigi Di Paolo, Maria Garganese, Tepas Kapadia, Jurgen Schaefer, Hugh Wallace, Simon Wan, Bart de Keizer, Irmina Sefic Pasic, Julian Rogasch   +11 more
wiley   +1 more source

Research rigor and reproducibility in research education: A CTSA institutional survey

Journal of Clinical and Translational Science
We assessed the rigor and reproducibility (R&R) activities of institutions funded by the National Center for Advancing Translational Sciences (NCTSA) through a survey and website search (N = 61).
Cathrine Axfors, Mario Malički, Steven N. Goodman   +2 more
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Understanding Sources of Variation to Improve the Reproducibility of Radiomics

Frontiers in Oncology, 2021
Radiomics is the method of choice for investigating the association between cancer imaging phenotype, cancer genotype and clinical outcome prediction in the era of precision medicine.
Binsheng Zhao
semanticscholar   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source