Results 61 to 70 of about 978,638 (304)
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Unified Behavioral Scoring for Preclinical Models
Frontiers in Neuroscience, 2020 Preclinical mental health research relies upon animal models, and whilst many encouraging advances are being made, reproducibility and translational relevance may be limited by sub-optimal testing or model choices.
David J. Harrison +7 more
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
First UK Reproducibility Network Annual Report (2023-2024) [PDF]
Il s\u27agit du rapport annuel 2023-2024 de l\u27UK Reproducibility Network (UKRN) au sujet de la Science Ouverte avec des exemples anglais de projets inspirant très ...
UK Reproducibility Network (UKRN)
core
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
eds-book/reproducibility-challenge-2023: Version v08.02.2024
<h2>What's Changed</h2> <ul> <li>Update README.md by @annefou in https://github.com/eds-book/reproducibility-challenge-2023/pull/1</li> <li>update general information for the reproducibility challenge by @annefou in ...
Sebastian Luna-Valero +2 more
core +1 more source
The Reproducibility of Lists of Differentially Expressed Genes in Microarray Studies [PDF]
, 2007 Reproducibility is a fundamental requirement in scientific experiments and clinical contexts. Recent publications raise concerns about the reliability of microarray technology because of the apparent lack of agreement between lists of differentially ...
Roderick V. Jensen +49 more
core +1 more source
RNA‐related functions of BRCA2 in transcription, replication, and genome stability
FEBS Letters, EarlyView.Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda +2 more
wiley +1 more source
DiagnosticsObjectives: To evaluate the reproducibility of measurements of breech progression angle (BPA) by transperineal ultrasound (US) before and after its standardization by applying an image-based checklist.
Ana M. Fidalgo +10 more
doaj +1 more source