Results 81 to 90 of about 978,638 (304)

Registration and reporting of clinical trials affiliated with California universities and with primary completion date from 2014 to 2017

Trials
Background Public information on US clinical trials is shared through the ClinicalTrials.gov registry. This study’s goal was to determine prospective registration, results reporting, trial registration number reporting, and publication accessibility ...
Mario Malički, Vladislav Nachev, Susanne Wieschowski, Nicole Hildebrand, Stefanie Gestrich, Samruddhi Yerunkar, Emmanuel Zavalis, Benjamin Gregory Carlisle, Delwen L. Franzen, Maia Salholz-Hillel, Steven N. Goodman, Daniel Strech   +11 more
doaj   +1 more source

Enhancing E-Government Services through State-of-the-Art, Modular, and Reproducible Architecture over Large Language Models

Applied Sciences
Integrating Large Language Models (LLMs) into e-government applications has the potential to improve public service delivery through advanced data processing and automation.
George Papageorgiou, Vangelis Sarlis, Manolis Maragoudakis, Christos Tjortjis   +3 more
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Intra and Inter-Rater Variability in the Interpretation of White Blood Cell Scintigraphy of Hip and Knee Prostheses

Diagnostics
Background: White blood cell (WBC) scintigraphy plays a major role in the diagnostic approach to periprosthetic infections. Although the procedure has been standardized by the publication of several guidelines, the interpretation of this technique may be
Giuseppe Campagna, Chiara Lauri, Ringo Manta, Roberta Ottaviani, Walter Davide Vella, Alberto Signore   +5 more
doaj   +1 more source

Progress on reproducibility [PDF]

Science, 2018
Ideas supported by well-defined and clearly described methods and evidence are one of the cornerstones of science. After several publications indicated that a substantial number of scientific reports may not be readily reproducible, the scientific community and public began engaging in discussions about mechanisms to measure and enhance the ...
openaire   +2 more sources

Research Reproducibility 2016: Opening Remarks

, 2016
Research Reproducibility Conference 2016, University of Utah.
Melissa Rethlefsen, Andy Weyrich
core  

Reproducibility in Natural Language Processing: A Case Study of Sentiment Classification

, 2022
reservedDue to the advance of knowledge and technology, the fields of Artificial Intelligence (AI) and Machine Learning (ML) have grown in recent years leading to a significant increase of published papers.
MINZONI, RICCARDO
core  

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Grand Rounds: Research Reproducibility - Robert Ricci (11-07-2017)

, 2018
Spencer S. Eccles Health Sciences Library Grand Rounds: Research Reproducibility (GRRR). "Software for Reproducibility" Presented by Rob Ricci, Research Associate Professor at the University of Utah School of Computing, College of Engineering. GRRR is a
Robert Ricci
core  

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source