Results 181 to 190 of about 1,463,180 (385)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

The IFNγ‐CIITA‐MHC II axis modulates melanoma cell susceptibility to NK‐cell‐mediated cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Natural killer (NK) cells play a central role in anti‐melanoma immunity. However, melanoma cells adapt during co‐culture by upregulating CIITA and MHC II in response to interferon gamma (IFNγ), thereby evading NK‐cell lysis. Blocking IFNγ signaling or treatment with dimethyl fumarate/simvastatin counteracts this immune escape and maintains NK‐cell ...
Lena C. M. Krause   +6 more
wiley   +1 more source

Inter- and intra-observer reliability of the Ergonomic Screening and Prioritization Tool to assess the risk level of work-related musculoskeletal disorders in nurses [PDF]

open access: yesطب کار
Introduction: Musculoskeletal Disorders (MSDs) are among the most common occupational diseases, and ergonomics and occupational health engineering specialists need reliable and valid methods for assessing high-risk activities and the factors contributing
Niloofar Rahgoshay   +4 more
doaj  

Phase-scan analysis results for the first drift tube linac module in the Ground Test Accelerator: data reproducibility and comparison to simulations

open access: green, 2002
K. F. Johnson   +9 more
openalex   +2 more sources

Reproducibility of Estradiol and Testosterone Levels in Postmenopausal Women Over 5 Years: Results From the Breakthrough Generations Study [PDF]

open access: hybrid, 2014
Michael E. Jones   +6 more
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

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