Results 51 to 60 of about 630,563 (312)
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
An analysis of key indicators of reproducibility in radiology
Insights into Imaging, 2020 Background Given the central role of radiology in patient care, it is important that radiological research is grounded in reproducible science. It is unclear whether there is a lack of reproducibility or transparency in radiologic research.
Bryan D. Wright +6 more
doaj +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
RELIABILITY OF A NEW BAROPODOMETRY PLATFORM DURING BAREFOOT WALKING IN HEALTHY ADULTS [PDF]
Acta Ortopédica BrasileiraObjective: To expand existing knowledge on gait parameters in a healthy population using a baropodometer and to ensure the reliability of the equipment.
Silvia Iovine Kobata +3 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Assessment of physical fitness among non-athlete adolescents: Effect of familiarization sessions
Baltic Journal of Health and Physical Activity, 2020 Background: The validity and reliability of fitness tests are described in the literature; however, the effects of familiarization sessions on motor performance have not yet been studied.
DIOGO HENRIQUE CONSTANTINO COLEDAM +1 more
doaj +1 more source
Results of an attempt to reproduce the STAP phenomenon [PDF]
F1000Research, 2015 In 2014, Obokata and colleagues reported their observation of a novel cell reprogramming phenomenon they named ‘stimulus-triggered acquisition of pluripotency’ (STAP). The most conclusive evidence for the pluripotency of so-called STAP cells was the purported ability of such cells to contribute to chimera formation.
openaire +3 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Reproducibility, reliability and validity of measurements obtained from Cecile3 digital models
Brazilian Oral Research, 2009 The aim of this study was to determine the reproducibility, reliability and validity of measurements in digital models compared to plaster models. Fifteen pairs of plaster models were obtained from orthodontic patients with permanent dentition before ...
Gustavo Adolfo Watanabe-Kanno +4 more
doaj +1 more source
Reproducibility and replication of research results
International Journal on Software Tools for Technology TransferAbstract While a reproducible research result can be independently confirmed by third parties using artifacts provided by the original authors, replicating a research result means to independently obtain it using new measurements, data, or implementations.
Dirk Beyer, Arnd Hartmanns
openaire +2 more sources