Results 61 to 70 of about 630,563 (312)

A Thorough Reproducibility Study on Sentiment Classification: Methodology, Experimental Setting, Results [PDF]

, 2023
Giorgio Maria Di Nunzio, Riccardo Minzoni   +1 more
openalex   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Agreement Between the WHOQOL-BREF Chinese and Taiwanese Versions in the Elderly

Journal of the Formosan Medical Association, 2009
The brief version of the World Health Organization Quality of Life instrument (WHOQOL-BREF), including four domains, has been culturally adapted into Taiwan Chinese and Taiwanese versions for different targeted populations of elderly people.
Chi-Wen Chien, Jung-Der Wang, Grace Yao, I-Ping Hsueh, Ching-Lin Hsieh   +4 more
doaj   +1 more source

Utilizing stability criteria in choosing feature selection methods yields reproducible results in microbiome data [PDF]

, 2020
Lingjing Jiang, Niina Haiminen, Anna Paola Carrieri, Shi Huang, Yoshiki Vázquez‐Baeza, Laxmi Parida, Ho‐Cheol Kim, Austin D. Swafford, Rob Knight, Loki Natarajan   +9 more
openalex   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Comparison of the Reproducibility of Various Tooth Color Measurement Techniques

Journal of Dental School
Objective(s): Accurate shade selection is the most challenging step in the natural reconstruction of teeth in most cases. The most commonly used method for adapting the color of tooth and restorative materials is the visual matching of the tooth color ...
Marzieh Rohaninasab, Hamed Bahrami Maleki, Nastaran Dabiri Shahabi, Sadra Ahmady   +3 more
doaj   +1 more source

Data Sharing and Reproducibility of Results-Does It Matter for HIV Nursing? [PDF]

J Assoc Nurses AIDS Care, 2021
Relf MV, Overstreet K.
europepmc   +1 more source