Results 71 to 80 of about 1,117,074 (345)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

In Vitro Evaluation of Eslicarbazepine Delivery via Enteral Feeding Tubes [PDF]

, 2017
Purpose: The feasibility of preparing an eslicarbazepine acetate suspension using Aptiom tablets for administration via enteral feeding tubes was evaluated.
Dave, Vivek S, Hughes, Susan, Reindel, Kristin, Zhao, Fang   +3 more
core   +2 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

An analysis of key indicators of reproducibility in radiology

Insights into Imaging, 2020
Background Given the central role of radiology in patient care, it is important that radiological research is grounded in reproducible science. It is unclear whether there is a lack of reproducibility or transparency in radiologic research.
Bryan D. Wright, Nam Vo, Johnny Nolan, Austin L. Johnson, Tyler Braaten, Daniel Tritz, Matt Vassar   +6 more
doaj   +1 more source

Reproducibility, accuracy and performance of the Feltor code and library on parallel computer architectures [PDF]

, 2018
Feltor is a modular and free scientific software package. It allows developing platform independent code that runs on a variety of parallel computer architectures ranging from laptop CPUs to multi-GPU distributed memory systems. Feltor consists of both a
Einkemmer, Lukas, Gutierrez-Milla, Albert, Held, Markus, Iakymchuk, Roman, Saez, Xavier, Wiesenberger, Matthias   +5 more
core   +2 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

RELIABILITY OF A NEW BAROPODOMETRY PLATFORM DURING BAREFOOT WALKING IN HEALTHY ADULTS [PDF]

Acta Ortopédica Brasileira
Objective: To expand existing knowledge on gait parameters in a healthy population using a baropodometer and to ensure the reliability of the equipment.
Silvia Iovine Kobata, Cynthia Rossetti Portela Alves, Marcelo Grossi Araújo, Flavia Vasques Bittencourt   +3 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Assessment of physical fitness among non-athlete adolescents: Effect of familiarization sessions

Baltic Journal of Health and Physical Activity, 2020
Background: ‪The validity and reliability of fitness tests are described in the literature; however, the effects of familiarization sessions on motor performance have not yet been studied.
DIOGO HENRIQUE CONSTANTINO COLEDAM, RODRIGO DIAS CARIA DE OLIVEIRA   +1 more
doaj   +1 more source

Results of an attempt to reproduce the STAP phenomenon [PDF]

F1000Research, 2015
In 2014, Obokata and colleagues reported their observation of a novel cell reprogramming phenomenon they named ‘stimulus-triggered acquisition of pluripotency’ (STAP). The most conclusive evidence for the pluripotency of so-called STAP cells was the purported ability of such cells to contribute to chimera formation.
openaire   +3 more sources