Results 21 to 30 of about 7,412 (168)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Replication Study: Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

eLife, 2019
As part of the Reproducibility Project: Cancer Biology we published a Registered Report (Evans et al., 2015), that described how we intended to replicate selected experiments from the paper ‘Wnt activity defines colon cancer stem cells and is regulated ...
Anthony Essex, Javier J. Pineda, Grishma Acharya, Hong Xin, James A. Evans, E. Iorns, Rachel Tsui, Alexandria Denis, N. Perfito, Timothy M. Errington   +9 more
semanticscholar   +1 more source

Cross-oncopanel study reveals high sensitivity and accuracy with overall analytical performance depending on genomic regions

Genome Biology, 2021
Targeted sequencing using oncopanels requires comprehensive assessments of accuracy and detection sensitivity to ensure analytical validity. By employing reference materials characterized by the U.S.
Bin-Sheng Gong, Dan Li, Rebecca Kusko, N. Novoradovskaya, Yifan Zhang, Shang-Zi Wang, C. Pabón-Peña, Zhihong Zhang, Kevin Lai, W. Cai, Jennifer S. Lococo, E. Lader, T. Richmond, V. Mittal, Liang-Chun Liu, Donald J. Johann, J. Willey, P. Bushel, Ying Yu, Chang Xu, Guangchun Chen, Daniel L Burgess, S. Cawley, K. Giorda, N. Haseley, F. Qiu, Katherine Wilkins, Hanane Arib, C. Attwooll, Kevin Babson, Long-Long Bao, Wen-Jun Bao, A. Lucas, H. Best, Ambica Bhandari, Halil Bisgin, J. Blackburn, Thomas M Blomquist, L. Boardman, Blake Burgher, D. Butler, Chia-Jung Chang, A. Chaubey, Tao Chen, M. Chierici, Christopher R. Chin, D. Close, J. Conroy, J. Coleman, D. Craig, Erin L. Crawford, Á. del Pozo, Ira W. Deveson, D. Duncan, A. Eterovic, Xiao-Hui Fan, Jonathan Foox, Cesare Furlanello, Abhisek Ghosal, S. Glenn, Mei-Jian Guan, C. Haag, X. Hang, S. Happe, Brittany Hennigan, Jennifer A. Hipp, H. Hong, Kyle Z. Horvath, Jian-Hong Hu, L. Hung, M. Jarosz, J. Kerkhof, B. Kipp, David P. Kreil, P. Łabaj, P. Lapunzina, Peng Li, Quan-Zhen Li, Weihua Li, Zhi-Guang Li, Yu Liang, Shaoqing Liu, Zhi-Chao Liu, Charles Ma, Narasimha Marella, R. Martín-Arenas, D. Megherbi, Qing-Chang Meng, P. Mieczkowski, Tom B. Morrison, D. Muzny, B. Ning, Barbara L. Parsons, C. Paweletz, M. Pirooznia, Wu-Bin Qu, Amelia Raymond, Paul M. Rindler, R. Ringler, B. Sadiković, A. Scherer, E. Schulze, R. Sebra, R. Shaknovich, Q. Shi, Tie-Liu Shi, J. C. Silla-Castro, Melissa L. Smith, M. López, Ping Song, Daniel B. Stetson, Maya Strahl, A. Stuart, Julianna G. Supplee, P. Szankasi, Hao Tan, Lin-ya Tang, Yong-Hui Tao, S. Thakkar, D. Thierry-Mieg, J. Thierry-Mieg, V. Thodima, David Thomas, B. Tichy, N. Tom, Elena Vallespín García, Suman Verma, K. Walker, Charles Wang, Jun-Wen Wang, Yexun Wang, Z. Wen, V. Wirta, Lei-Hong Wu, Chun-Lin Xiao, W. Xiao, Shibei Xu, Mary Yang, J. Ying, Shun H. Yip, Guang-Liang Zhang, Sa Zhang, Mei-Ru Zhao, Yuan-Ting Zheng, Xiao-Yue Zhou, C. Mason, T. Mercer, W. Tong, Le-Ming Shi, W. Jones, Joshua Xu   +150 more
semanticscholar   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Registered Report: COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

eLife, 2016
The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by conducting replications of selected experiments from a number of high-profile papers in the field of cancer biology. The papers,
Vidhu Sharma, Lisa Young, Miguel A. S. Cavadas, Kate Owen   +3 more
semanticscholar   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Registered report: Systematic identification of genomic markers of drug sensitivity in cancer cells

eLife, 2016
The Reproducibility Project: Cancer Biology seeks to address growing concerns about the reproducibility in scientific research by conducting replications of selected experiments from a number of high-profile papers in the field of cancer biology.
J. P. Vanden Heuvel, J. Bullenkamp
semanticscholar   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source