Results 71 to 80 of about 614,762 (328)

Advancing computational reproducibility in the Dataverse data repository platform [PDF]

arXiv, 2020
Recent reproducibility case studies have raised concerns showing that much of the deposited research has not been reproducible. One of their conclusions was that the way data repositories store research data and code cannot fully facilitate reproducibility due to the absence of a runtime environment needed for the code execution.
arxiv  

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

RR by R in Official Statistics [PDF]

Revista Română de Statistică, 2016
Nowadays there is a growing alarm about scientific research results that cannot be reproduced. The reasons comprise increased levels of control, complexity of experiments and statistics, and also time pressures on researchers.
Ciprian ALEXANDRU, Nicoleta CARAGEA
doaj  

Sensitivity of Radiocarbon Sum Calibration

Journal of Computer Applications in Archaeology, 2020
Sum calibration has become a standard tool for demographic studies, even though the methodology itself is far from uncontroversial. In addition to fundamental methodological criticism, questions are frequently raised about the sample size and data ...
Martin Hinz
doaj   +1 more source

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

FEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze, Stéphane Canaan, Alexandre Gouzy, Pierre Santucci   +3 more
wiley   +1 more source

The Economics of Reproducibility in Preclinical Research

PLOS Biology, 2015
Low reproducibility rates within life science research undermine cumulative knowledge production and contribute to both delays and costs of therapeutic drug development. An analysis of past studies indicates that the cumulative (total) prevalence of irreproducible preclinical research exceeds 50%, resulting in approximately US$28,000,000,000 (US$28B ...
Freedman, Leonard P., Cockburn, Iain M., Simcoe, Timothy S.   +2 more
openaire   +6 more sources

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Caching and Distributing Statistical Analyses in R

Journal of Statistical Software, 2008
We present the cacher package for R, which provides tools for caching statistical analyses and for distributing these analyses to others in an efficient manner.
Roger D. Peng
doaj  

Reproducibility, Replicability, and Repeatability: A survey of reproducible research with a focus on high performance computing [PDF]

Computer Science Review, 2024, 53, pp.100655
Reproducibility is widely acknowledged as a fundamental principle in scientific research. Currently, the scientific community grapples with numerous challenges associated with reproducibility, often referred to as the ''reproducibility crisis.'' This crisis permeated numerous scientific disciplines.
arxiv   +1 more source