Results 101 to 110 of about 1,255,722 (301)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Assisted human reproduction: social, ethical and legal factors: a one day private conference organised by the Commission on Human Reproduction.

, 2001
One might say the object of regulation is to set and maintain the acceptable limits of what is being regulated. To set the minimum standard that is compatible with the social and ethical.
Commission on Assisten Human Reproduction.
core  

Extracellular vesicles and its advances in female reproduction

, 2018
Intercellular communication is an essential mechanism for development and maintenance of multicellular organisms. Extracellular vesicles (EVs) were recently described as new players in the intercellular communication.
Bridi, Alessandra, de ávila, Ana Clara Faquineli Cavalcante Mendes, da Silveira, Juliano Coelho, Gimenes, Lindsay Unno [UNESP], Meirelles, Flávio Vieira, Perecin, Felipe, Andrade, Gabriella Mamede   +6 more
core   +1 more source

Supportive Intervention for Unmet Needs Among Breast Cancer Patients and Their Spousal Caregivers: A Randomized Controlled Trial

Breast Cancer: Targets and Therapy
Qian Zhang,1,* Shan Wang,1,* Jiajia Zhang,1 Tianyu Chu,1 Xian Chen,1 Linlin Ma,1 Hui Zhou,1 Yibo Wu,1 Dewu Xu,2 Kai Jiang3 1Obstetrics, Gynecology and Reproduction Research Center, Affiliated Hospital of Jiangnan University, Wuxi, People ...
Zhang Q, Wang S, Zhang J, Chu T, Chen X, Ma L, Zhou H, Wu Y, Xu D, Jiang K   +9 more
doaj  

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Questionnements éthiques dans les recherches sur la reproduction humaine

, 2006
Ethical questioning in human reproduction ...
Boué, André
core  

Effectiveness of a Care Plan Based on the Multi-Theory Model in Reducing Fear of Disease Progression and Improving Quality of Life in Breast Cancer Patients: A Randomized Controlled Trial

Breast Cancer: Targets and Therapy
Jiajia Zhang,1,* Jiaru Zhuang,1,* Xian Chen,1 Tianyu Chu,1 Qian Zhang,1 Linlin Ma,1 Hui Zhou,1 Yibo Wu,1 Ling Chen2 1Obstetrics, Gynecology and Reproduction Research Center, Affiliated Hospital of Jiangnan University, Wuxi, People’s ...
Zhang J, Zhuang J, Chen X, Chu T, Zhang Q, Ma L, Zhou H, Wu Y, Chen L   +8 more
doaj  

Linking CD38 Cell Surface Expression to the Unique Calcium Flux Properties in Human Peripheral B Lymphocytes Following anti-IgM and anti-IgG Stimulation

Journal of Immunology Research
CD38 serves as a marker for defining subsets of immune cells; however, being an ectoenzyme, it also plays a crucial part in modulating immunometabolic homeostasis, has immense potential to influence the microenvironment of tissues, functions as a ...
Viktória Temesfői, Péter Kaltenecker, Anna Nörenberg, Tímea Serény-Litvai, Ambrus Kaposi, Emese Mezősi   +5 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source