Results 71 to 80 of about 679,548 (318)

Comparison Between Radiographic Vertebral Left Atrial Size (VLAS) and Echocardiographic Methods for Predicting Left Atrial Remodeling in Dogs With Mitral Valve Disease

Veterinary Medicine International
Conclusions and Clinics Relevance: VLAS has a positive relationship and important correlation with the echocardiographic variables and MINE score. Associated with its higher accessibility in clinical routine is a potential diagnostic method to detect ...
Natália Babolim Pereira, Guilherme Andraus Bispo, Maurício Peres Carneiro, Ricardo de Souza Buzo, Daniela Ribas Jané, Laís Calazans Menescal Linhares, Paulo Sergio Patto dos Santos, Luciana Del Rio Pinoti, Wagner Luis Ferreira   +8 more
doaj   +1 more source

Effects of vaginal vs oral progesterone supplementation before embryo transfer on live birth rates and levels: a randomized trial

Reproduction and Fertility
The increase in frozen embryo transfers (FETs) is a consequence of advances in embryo vitrification and the implementation of genetic screening of embryos.
Gorka Barrenetxea, Olaia Prego, Ricardo Celis, Edurne Martínez, María De Las Heras, Oihane Gómez, Olaia Aguirre, Sheila Samojluk, Julen Barrenetxea   +8 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

The incidence and outcomes of perinatal asphyxia in spontaneous extreme preterm birth: a retrospective cohort study

Journal of Perinatal Medicine
To determine the incidence and outcome of perinatal asphyxia (PA) in spontaneous extreme preterm birth (PTB) between 24 and 28 weeks gestation.
Faiz Zohal, van ’t Hof Eline, de Boer Marjon, de Haan Timo R., Weissenbruch Mirjam, Klautz Arthur, Lippes Pien, Mol Ben Willem, de Groot Christianne, Bakker Petra   +9 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Parvovirus B19 Infection in Pregnancy—Course of the Disease, Fetal Complications and Management Tools: A Case Series and Literature Review

Children
Parvovirus B19 is a virus that causes a common and usually harmless infection in both children and adults. If the virus is transmitted transplacentally during pregnancy, it can have serious consequences for both the pregnant woman and the fetus ...
Olga Olejniczak, Jakub Kornacki, Daniel Boroń, Paweł Gutaj, Rafał Iciek, Ewa Wender-Ożegowska   +5 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Optimized heterologous in vitro fertilization with Iberian ibex sperm and domestic goat oocytes

Theriogenology Wild
Assisted reproductive technologies are key to maintain genetic stocks of endangered wild species, such as the Iberian ibex (Capra pyrenaica). Due to the low availability of ibex ovaries, heterologous in vitro fertilization (IVF) with domestic goat (Capra
Nuria Martínez de los Reyes, Melissa Carvajal-Serna, Inés Flores-Borobia, Pilar Marigorta, Patricia Peris-Frau, Julián Santiago-Moreno, Pablo Bermejo-Álvarez, Priscila Ramos-Ibeas   +7 more
doaj   +1 more source