Results 51 to 60 of about 451,555 (249)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Amplification of the basic reproduction number in cattle farm networks. [PDF]

PLoS ONE, 2018
The popularly known 20-80 rule or Pareto rule states that 20% of efforts leads to 80% of results. This rule has been applied to the study of infection transmission in contact networks, and specifically, contact networks between cattle farms.
Beatriz Vidondo
doaj   +1 more source

Estimating the basic reproduction number for COVID-19 in Western Europe.

PLoS ONE, 2021
ObjectiveTo estimate the basic reproduction number (R0) for COVID-19 in Western Europe.MethodsData (official statistics) on the cumulative incidence of COVID-19 at the start of the outbreak (before any confinement rules were declared) were retrieved in ...
Isabella Locatelli, Bastien Trächsel, Valentin Rousson   +2 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The Effective Reproduction Number of Pandemic Influenza [PDF]

Epidemiology, 2010
Timely estimation of the transmissibility of a novel pandemic influenza virus was a public health priority in 2009.We extended methods for prospective estimation of the effective reproduction number (Rt) over time in an emerging epidemic to allow for reporting delays and repeated importations.
Tsang, T, Lo, SV, Lau, MSY, Leung, PY, Liu, SH, Chuang, SK, Lau, EHY, Ho, LM, Cowling, BJ   +8 more
openaire   +4 more sources

Estimating the basic reproduction number at the beginning of an outbreak

PLOS ONE, 2022
We compare several popular methods of estimating the basic reproduction number, R 0 , focusing on the early stages of an epidemic, and assuming weekly reports of new infecteds.
Sawitree Boonpatcharanon, Jane M. Heffernan, Hanna Jankowski   +2 more
openaire   +4 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Reproduction number estimation using smoothing methods

Discover Public Health
The reproduction number is estimated to understand the potential spread of an infectious disease within a population. Current estimation methods can be broadly categorized into mathematical and statistical methodological frameworks.
Mahamadou Barro, Serge Manituo Aymar Somda, Cédric Stéphane Bationo, Bernard Eric Agodio Daboné, Betty Kazanga, Fabrice Anyirékun Somé, Benjamin Roche, Jean Gaudart   +7 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source