Results 1 to 10 of about 290,067 (258)

Metformin in Reproductive Biology [PDF]

Frontiers in Endocrinology, 2018
Initially produced in Europe in 1958, metformin is still one of the most widely prescribed drugs to treat type II diabetes and other comorbidities associated with insulin resistance.
Melanie Faure, Michael J. Bertoldo, Rita Khoueiry, Alice Bongrani, François Brion, Cecilia Giulivi, Cecilia Giulivi, Joelle Dupont, Pascal Froment   +8 more
doaj   +8 more sources

Mitochondrial biology in reproduction [PDF]

Reproductive Medicine and Biology, 2011
AbstractMitochondrial biology plays an important role in the reproductive process, with influence on germ cell development and quality as well as embryonic development and reproductive success. This review outlines the role of mitochondrial genetics and function in reproductive biology, including a discussion of general mitochondrial function, genetics
Matthew V, Cannon, Kumiko, Takeda, Carl A, Pinkert   +2 more
openaire   +2 more sources

Molecular signatures of labor and nonlabor myometrium with parsimonious classification from 2 calcium transporter genes

JCI Insight, 2021
Clinical phenotyping of term and preterm labor is imprecise, and disagreement persists on categorization relative to underlying pathobiology, which remains poorly understood.
William E. Ackerman IV, Catalin S. Buhimschi, Ali Snedden, Taryn L. Summerfield, Guomao Zhao, Irina A. Buhimschi   +5 more
doaj   +1 more source

Spheroids as a model for endometriotic lesions

JCI Insight, 2023
The development and progression of endometriotic lesions are poorly understood, but immune cell dysfunction and inflammation are closely associated with the pathophysiology of endometriosis.
Yong Song, Gregory W. Burns, Niraj R. Joshi, Ripla Arora, J. Julie Kim, Asgerally T. Fazleabas   +5 more
doaj   +1 more source

Regulatory T cells are paramount effectors in progesterone regulation of embryo implantation and fetal growth

JCI Insight, 2023
Progesterone (P4) is essential for embryo implantation, but the extent to which the pro-gestational effects of P4 depend on the maternal immune compartment is unknown.
Ella S. Green, Lachlan M. Moldenhauer, Holly M. Groome, David J. Sharkey, Peck Y. Chin, Alison S. Care, Rebecca L. Robker, Shaun R. McColl, Sarah A. Robertson   +8 more
doaj   +1 more source

Signaling through retinoic acid receptors is essential for mammalian uterine receptivity and decidualization

JCI Insight, 2021
Retinoic acid (RA) signaling has long been speculated to regulate embryo implantation, because many enzymes and proteins responsible for maintaining RA homeostasis and transducing RA signals are tightly regulated in the endometrium during this critical ...
Yan Yin, Meade E. Haller, Sangappa B. Chadchan, Ramakrishna Kommagani, Liang Ma   +4 more
doaj   +1 more source

Loss-of-function mutations in CFAP57 cause multiple morphological abnormalities of the flagella in humans and mice

JCI Insight, 2023
Multiple morphological abnormalities of the sperm flagella (MMAF) are the most severe form of asthenozoospermia due to impaired axoneme structure in sperm flagella. Dynein arms are necessary components of the sperm flagellar axoneme.
Ao Ma, Jianteng Zhou, Haider Ali, Tanveer Abbas, Imtiaz Ali, Zubair Muhammad, Sobia Dil, Jing Chen, Xiongheng Huang, Hui Ma, Daren Zhao, Beibei Zhang, Yuanwei Zhang, Wasim Shah, Basit Shah, Ghulam Murtaza, Furhan Iqbal, Muzammil Ahmad Khan, Asad Khan, Qing Li, Bo Xu, Limin Wu, Huan Zhang, Qinghua Shi   +23 more
doaj   +1 more source

Transcriptome and DNA methylome analyses reveal underlying mechanisms for the racial disparity in uterine fibroids

JCI Insight, 2022
Uterine fibroids (leiomyomas) affect Black women disproportionately compared with women of other races and ethnicities in terms of prevalence, incidence, and severity of symptoms. The causes of this racial disparity are essentially unknown.
Emmanuel N. Paul, Joshua A. Grey, Tyler J. Carpenter, Zachary B. Madaj, Kin H. Lau, Scott A. Givan, Gregory W. Burns, Ronald L. Chandler, Ganesa R. Wegienka, Hui Shen, Jose M. Teixeira   +10 more
doaj   +1 more source

A single-cell atlas of the myometrium in human parturition

JCI Insight, 2022
Parturition is a well-orchestrated process characterized by increased uterine contractility, cervical ripening, and activation of the chorioamniotic membranes; yet, the transition from a quiescent to a contractile myometrium heralds the onset of labor ...
Roger Pique-Regi, Roberto Romero, Valeria Garcia-Flores, Azam Peyvandipour, Adi L. Tarca, Errile Pusod, Jose Galaz, Derek Miller, Gaurav Bhatti, Robert Para, Tomi Kanninen, Ola Hadaya, Carmen Paredes, Kenichiro Motomura, Jeffrey R. Johnson, Eunjung Jung, Chaur-Dong Hsu, Stanley M. Berry, Nardhy Gomez-Lopez   +18 more
doaj   +1 more source

Phytoestrogens and reproductive biology [PDF]

Reproductive Medicine and Biology, 2005
Phytoestrogens are naturally occurring plant substances that can either mimic or antagonize the action of endogenous estrogens. This is because of the similarity of the functional structure of phytoestrogens and endogenous estrogens. In premenopausal women, phytoestrogen intake might induce a decrease in luteinizing hormone, follicle‐stimulating ...
openaire   +2 more sources