Results 1 to 10 of about 2,140,003 (260)

Molecular signatures of labor and nonlabor myometrium with parsimonious classification from 2 calcium transporter genes

JCI Insight, 2021
Clinical phenotyping of term and preterm labor is imprecise, and disagreement persists on categorization relative to underlying pathobiology, which remains poorly understood.
William E. Ackerman IV, Catalin S. Buhimschi, Ali Snedden, Taryn L. Summerfield, Guomao Zhao, Irina A. Buhimschi   +5 more
doaj   +1 more source

The lipase cofactor CGI58 controls placental lipolysis

JCI Insight, 2023
In eutherians, the placenta plays a critical role in the uptake, storage, and metabolism of lipids. These processes govern the availability of fatty acids to the developing fetus, where inadequate supply has been associated with substandard fetal growth.
Jennifer Guerrero-Santoro, Mayumi Morizane, Soo-Young Oh, Takuya Mishima, Julie P. Goff, Ibrahim Bildirici, Elena Sadovsky, Yingshi Ouyang, Vladimir A. Tyurin, Yulia Y. Tyurina, Valerian E. Kagan, Yoel Sadovsky   +11 more
doaj   +1 more source

Metformin in Reproductive Biology

Frontiers in Endocrinology, 2018
Initially produced in Europe in 1958, metformin is still one of the most widely prescribed drugs to treat type II diabetes and other comorbidities associated with insulin resistance.
Melanie Faure, Michael J. Bertoldo, Rita Khoueiry, Alice Bongrani, François Brion, Cecilia Giulivi, Cecilia Giulivi, Joelle Dupont, Pascal Froment   +8 more
doaj   +1 more source

Fetal maturation revealed by amniotic fluid cell-free transcriptome in rhesus macaques

JCI Insight, 2022
Accurate estimate of fetal maturity could provide individualized guidance for delivery of complicated pregnancies. However, current methods are invasive, have low accuracy, and are limited to fetal lung maturation.
Augusto F. Schmidt, Daniel J. Schnell, Kenneth P. Eaton, Kashish Chetal, Paranthaman S. Kannan, Lisa A. Miller, Claire A. Chougnet, Daniel T. Swarr, Alan H. Jobe, Nathan Salomonis, Beena D. Kamath-Rayne   +10 more
doaj   +1 more source

X-linked RBBP7 mutation causes maturation arrest and testicular tumors

The Journal of Clinical Investigation, 2023
Maturation arrest (MA) is a subtype of non-obstructive azoospermia, and male infertility is a known risk factor for testicular tumors. However, the genetic basis for many affected individuals remains unknown.
Jingping Li, Huimei Zheng, Jiaru Hou, Jianhua Chen, Fengbin Zhang, Xiaohang Yang, Fan Jin, Yongmei Xi   +7 more
doaj   +1 more source

Maternal CXCR4 deletion results in placental defects and pregnancy loss mediated by immune dysregulation

JCI Insight, 2023
CXCR4 is a key regulator of the development of NK cells and DCs, both of which play an important role in early placental development and immune tolerance at the maternal-fetal interface. However, the role of CXCR4 in pregnancy is not well understood. Our
Fang Lyu, Chase Burzynski, Yuan yuan Fang, Aya Tal, Alice Y. Chen, Jacqueline Kisa, Kriti Agrawal, Yuval Kluger, Hugh S. Taylor, Reshef Tal   +9 more
doaj   +1 more source

Spheroids as a model for endometriotic lesions

JCI Insight, 2023
The development and progression of endometriotic lesions are poorly understood, but immune cell dysfunction and inflammation are closely associated with the pathophysiology of endometriosis.
Yong Song, Gregory W. Burns, Niraj R. Joshi, Ripla Arora, J. Julie Kim, Asgerally T. Fazleabas   +5 more
doaj   +1 more source

Regulatory T cells are paramount effectors in progesterone regulation of embryo implantation and fetal growth

JCI Insight, 2023
Progesterone (P4) is essential for embryo implantation, but the extent to which the pro-gestational effects of P4 depend on the maternal immune compartment is unknown.
Ella S. Green, Lachlan M. Moldenhauer, Holly M. Groome, David J. Sharkey, Peck Y. Chin, Alison S. Care, Rebecca L. Robker, Shaun R. McColl, Sarah A. Robertson   +8 more
doaj   +1 more source

WNK1 regulates uterine homeostasis and its ability to support pregnancy

JCI Insight, 2020
WNK1 (with no lysine [K] kinase 1) is an atypical kinase protein ubiquitously expressed in humans and mice. A mutation in its encoding gene causes hypertension in humans, which is associated with abnormal ion homeostasis.
Ru-pin Alicia Chi, Tianyuan Wang, Chou-Long Huang, San-pin Wu, Steven L. Young, John P. Lydon, Francesco J. DeMayo   +6 more
doaj   +1 more source

Signaling through retinoic acid receptors is essential for mammalian uterine receptivity and decidualization

JCI Insight, 2021
Retinoic acid (RA) signaling has long been speculated to regulate embryo implantation, because many enzymes and proteins responsible for maintaining RA homeostasis and transducing RA signals are tightly regulated in the endometrium during this critical ...
Yan Yin, Meade E. Haller, Sangappa B. Chadchan, Ramakrishna Kommagani, Liang Ma   +4 more
doaj   +1 more source