Results 11 to 20 of about 290,067 (258)
WNK1 regulates uterine homeostasis and its ability to support pregnancy
JCI Insight, 2020 WNK1 (with no lysine [K] kinase 1) is an atypical kinase protein ubiquitously expressed in humans and mice. A mutation in its encoding gene causes hypertension in humans, which is associated with abnormal ion homeostasis.
Ru-pin Alicia Chi +6 more
doaj +1 more source
Radiotherapy exposure directly damages the uterus and causes pregnancy loss
JCI Insight, 2023 Female cancer survivors are significantly more likely to experience infertility than the general population. It is well established that chemotherapy and radiotherapy can damage the ovary and compromise fertility, yet the ability of cancer treatments to ...
Meaghan J. Griffiths +17 more
doaj +1 more source
Apoptosis in reproductive biology [PDF]
Cell Death & Differentiation, 1997 Recent studies aimed at a greater understanding of the occurrence and regulation of cell death in reproductive biology provide a promising new direction for novel approaches to understanding normal and pathological aspects of reproduction. Several instances of physiologically occurring cell death (programmed cell death, PCD), associated with ...
openaire +3 more sources
The lipase cofactor CGI58 controls placental lipolysis
JCI Insight, 2023 In eutherians, the placenta plays a critical role in the uptake, storage, and metabolism of lipids. These processes govern the availability of fatty acids to the developing fetus, where inadequate supply has been associated with substandard fetal growth.
Jennifer Guerrero-Santoro +11 more
doaj +1 more source
Fetal maturation revealed by amniotic fluid cell-free transcriptome in rhesus macaques
JCI Insight, 2022 Accurate estimate of fetal maturity could provide individualized guidance for delivery of complicated pregnancies. However, current methods are invasive, have low accuracy, and are limited to fetal lung maturation.
Augusto F. Schmidt +10 more
doaj +1 more source
Mitochondria Biology in Reproductive Function
Antioxidants, 2022 Mitochondria are multitasking organelles involved in the maintenance of cell homeostasis [...]
Carla Tatone, Giovanna Di Emidio
doaj +1 more source
Biology, economy and reproduction [PDF]
Acta Obstetricia et Gynecologica Scandinavica, 2007 Economic theories have been used to explain fertility patterns 1, 2. Reduced fertility in the Western world has been explained by changes in women's investment from child bearing to education and p...
openaire +2 more sources
X-linked RBBP7 mutation causes maturation arrest and testicular tumors
The Journal of Clinical Investigation, 2023 Maturation arrest (MA) is a subtype of non-obstructive azoospermia, and male infertility is a known risk factor for testicular tumors. However, the genetic basis for many affected individuals remains unknown.
Jingping Li +7 more
doaj +1 more source
JCI Insight, 2023 CXCR4 is a key regulator of the development of NK cells and DCs, both of which play an important role in early placental development and immune tolerance at the maternal-fetal interface. However, the role of CXCR4 in pregnancy is not well understood. Our
Fang Lyu +9 more
doaj +1 more source
The Journal of Clinical Investigation, 2023 BACKGROUND Severe, early-onset fetal growth restriction (FGR) causes significant fetal and neonatal mortality and morbidity. Predicting the outcome of affected pregnancies at the time of diagnosis is difficult, thus preventing accurate patient counseling.
Rebecca Spencer +19 more
doaj +1 more source