Results 111 to 120 of about 2,793,995 (298)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

The Reproductive Value in Distributed Optimal Control Models [PDF]

We show that in a large class of distributed optimal control models (DOCM), where population is described by a McKendrick type equation with an endogenous number of newborns, the reproductive value of Fisher shows up as part of the shadow price of the ...
Michael Kuhn, Stefan Wrzaczek, Alexia Prskawetz, Gustav Feichtinger   +3 more
core  

Reproductive cycle of Macrobrachium amazonicum females (Crustacea, Palaemonidae)

Brazilian Journal of Biology
Macrobrachium amazonicum is considered a favorite Brazilian species of freshwater prawn for cultivation as a result of its quick development and because it is easy to maintain in captivity.
CMS. Sampaio, RR. Silva, JA. Santos, SP. Sales   +3 more
doaj   +1 more source

Comprehensive Transcriptomic and Metabolomic Analysis Revealed the Functional Differences in Pigeon Lactation between Male and Female during the Reproductive Cycle. [PDF]

Animals (Basel), 2023
Fu Y, Song Y, Jiang D, Pan J, Li W, Zhang X, Chen W, Tian Y, Shen X, Huang Y.   +9 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Reproductive Cycle and Menstruation (Hindi Version)

Reproductive Cycle and Menstruation (Hindi Version) educational ...
Singh, Akanksha, Ulmann, Selina
core  

Epidemiological evidence on reproductive effects of persistent organochlorines in humans

, 2004
Organochlorines are widespread pollutants in humans. Concern about adverse reproductive effects of these compounds arises from accidental exposure of humans and experimental studies.
Bonde, JP, Toft, G, Giwercman, Aleksander, Hagmar, L, Giwercman, Aleksander,, Lund University.   +5 more
core   +1 more source

Environmental timing and control of reproduction in the powan of Loch Lomond 'Coregonus lavaretus (L) (Teleostei)' in relation to its pineal organ [PDF]

, 2012
The reproductive cycle of Coregonus lavaretus (L. ) in Loch Lomond was investigated by monthly sampling. The stages of the cycle occurred at the same time each year and were precisely timed.
O'Connell, William David
core   +1 more source

Biología reproductiva de la serpiente semiacuática Liophis semiaureus (Serpentes, Colubridae) en el nordeste de Argentina Reproductive biology of the semi-aquatic snake Liophis semiaureus (Serpentes, Colubridae) in the north-east of Argentina

Revista Chilena de Historia Natural, 2009
Las serpientes tienen una notable flexibilidad y diversidad en sus tácticas reproductivas, a pesar de ello, los estudios acerca de la biología reproductiva de especies sudamericanas en zonas subtropicales-templadas son escasos.
SOLEDAD M LÓPEZ, ALEJANDRO R GIRAUDO, VANESA ARZAMENDIA, MARGARITA CHIARAVIGLIO   +3 more
doaj