Results 121 to 130 of about 2,793,995 (298)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Who are the successful reproductive health clinician-researchers?

open access: yes, 2016
Health research output from the Pacific Islands is low. Improving clinicians important role in generating and utilizing research evidence to improve patient care has been the aim of research collaborations, governments and funding agencies.
Latu, R   +3 more
core   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

open access: yesMolecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic   +15 more
wiley   +1 more source

Cultural change and the reproductive cycle

open access: yes
What we regard as 'normal' or 'natural' with respect to human female reproductive physiology differs greatly from the reproductive cycle experienced during most of human existence.
Dennis, Robert
core  

Reproductive parameters of the southern stingray Dasyatis americana in southern gulf of Mexico Parámetros reproductivos de la raya látigo americana Dasyatis americana en el sur del golfo de México

open access: yesLatin American Journal of Aquatic Research, 2012
The southern stingray Dasyatis americana (Hildebrand & Schroeder, 1928) is the most landed elasmobranch by small-scale fleets in southern gulf of Mexico. However, little is known of its life history parameters in this region.
Edith Ramírez-Mosqueda   +2 more
doaj  

VMHvllCckar cells dynamically control female sexual behaviors over the reproductive cycle. [PDF]

open access: yesNeuron, 2022
Yin L   +6 more
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

The reproductive cycle in teleost fish

open access: yes, 1981
Reproduction is a cyclic activity corresponding to an adaptation to the changing environment. Fish live in a variety of biota, leading to great diversity in their reproductive patterns.
Billard, Roland, Billard, R.
core  

Reproductive cycle and gonadal output of the Lessepsian jellyfish Cassiopea andromeda in NW Sicily (Central Mediterranean Sea). [PDF]

open access: yesPLoS One, 2023
Mammone M   +9 more
europepmc   +1 more source

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