Results 111 to 120 of about 1,087,820 (356)
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
Environmental Sciences EuropeIntroduction Nonsyndromic cleft lip and/or palate (NSCL/P) is a common congenital malformation with a complex etiology involving many environmental factors. Organophosphate flame retardants (OPFRs) are a class of emerging contaminants that are associated
Shujian Lin +9 more
doaj +1 more source
BMC Pregnancy and Childbirth, 2019 Background Evidence suggests that many women experience mistreatment during childbirth in health facilities across the world, but the magnitude of the problem is unknown. The occurrence of disrespect and abuse (D&A) in maternity care services affects the
Anna Galle +7 more
doaj +1 more source
FEBS Letters, EarlyView.Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli +10 more
wiley +1 more source
Reproductive genetics and health
Medizinische GenetikAbstract For those affected, infertility is linked to impaired overall health and reduced life expectancy. In particular, infertile individuals bear an increased risk for cardiovascular disease (CVD) and different types of cancer, partially due to lifestyle differences and to genetic alterations that cause both infertility and an ...
Margot J. Wyrwoll, Johanna Steingröver
openaire +2 more sources
Male reproductive health and yoga
International Journal of Yoga, 2013 Now-a-days reproductive health problems along with infertility in male is very often observed. Various Assisted Reproductive Technologies have been introduced to solve the problem, but common people cannot afford the cost of such procedures. Various ayurvedic and other alternative medicines, along with regular yoga practice are proven to be not only ...
Pallav Sengupta +2 more
openaire +4 more sources
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
Obesity and Reproductive Health
Journal of Family Planning and Reproductive Health Care, 2008 Edited by Philip Baker, Adam Balen, Lucilla Poston and Naveed SattarRCOG Press 2007. 286 pages. £48.00 paperback.ISBN 9781904752394In recent years, in the UK, the prevalence of obesity in women has...
openaire +2 more sources
FEBS Letters, EarlyView.This work presents the characterization of MvoDUF2193, a Methanococcus voltae (Mvo) protein from the domain of unknown function (DUF) 2193 family. We demonstrate that MvoDUF2193 binds a single [4Fe–4S] cluster per subunit and that cluster occupancy regulates the transition from an apo tetramer to a [4Fe–4S] monomeric form. This structural transition is
Emily M. Dieter +8 more
wiley +1 more source
Sexual and reproductive health status and health service utilisation of adolescents in four districts in Nepal [PDF]
, 2012 This study is the first part of an impact evaluation that documents the effectiveness of the National Adolescent Sexual and Reproductive Health Programme in Nepal led by the Family Health Division.
Acharya, Dev Raj +2 more
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