Results 171 to 180 of about 152,391 (254)

Widespread Gene Expression Divergence in Butterfly Sensory Tissues Plays a Fundamental Role During Reproductive Isolation and Speciation. [PDF]

Mol Biol Evol, 2022
Wu N, Evans E, van Schooten B, Meléndez-Rosa J, Ortiz Y, Planas Soto-Navarro SM, Van Belleghem SM, Counterman BA, Papa R, Zhang W.   +9 more
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Pollination niche shifts in sympatric globular cacti <i>Eriosyce</i>: Consequences on reproductive isolation and species formation. [PDF]

Plant Divers
Guerrero PC, Martínez-Harms J, Arroyo MTK, Eaton D, Meriño BM, Varas-Myrik A, Villalobos-Barrantes HM, Carvallo GO.   +7 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

The role of pheromones and temporal mechanisms in the reproductive isolation of Monochamus maculosus, Monochamus notatus, and Monochamus scutellatus (Coleoptera: Cerambycidae). [PDF]

Environ Entomol
Andrade SMM, McTavish MJ, Smith SM, Allison JD.   +3 more
europepmc   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Persistent Gene Flow Suggests an Absence of Reproductive Isolation in an African Antelope Speciation Model. [PDF]

Syst Biol
Wang X, Pedersen CT, Athanasiadis G, Garcia-Erill G, Hanghøj K, Bertola LD, Rasmussen MS, Schubert M, Liu X, Li Z, Lin L, Balboa RF, Jørsboe E, Nursyifa C, Liu S, Muwanika V, Masembe C, Chen L, Wang W, Moltke I, Siegismund HR, Albrechtsen A, Heller R.   +22 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Mismatch between pollen and pistil size causes asymmetric mechanical reproductive isolation across Phlox species. [PDF]

Evolution
Feller AF, Burgin G, Lewis NF, Prabhu R, Hopkins R.   +4 more
europepmc   +1 more source