Results 181 to 190 of about 1,448,748 (289)

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Immunoglobulin genes, reproductive isolation and vertebrate speciation. [PDF]

Immunol Cell Biol, 2022
Collins AM, Watson CT, Breden F.
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Radiation with reproductive isolation in the near-absence of phylogenetic signal. [PDF]

Sci Adv
Helmkampf M, Coulmance F, Heckwolf MJ, Acero P A, Balard A, Bista I, Dominguez OD, Frandsen PB, Torres-Oliva M, Santaquiteria A, Tavera J, Victor BC, Robertson DR, Betancur-R R, McMillan WO, Puebla O.   +15 more
europepmc   +1 more source

Two complementary genes in a presence-absence variation contribute to indica-japonica reproductive isolation in rice. [PDF]

Nat Commun, 2023
Wang D, Wang H, Xu X, Wang M, Wang Y, Chen H, Ping F, Zhong H, Mu Z, Xie W, Li X, Feng J, Zhang M, Fan Z, Yang T, Zhao J, Liu B, Ruan Y, Zhang G, Liu C, Liu Z.   +20 more
europepmc   +1 more source

Digest: On the temporal evolution of reproductive isolation* [PDF]

Evolution, 2017
openaire   +2 more sources

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Discovery of Genetically Distinct, Sympatric Coral Lineages With Temporal but Not Gametic Reproductive Isolation. [PDF]

Mol Ecol
Chamberland VF, Gómez-Corrales M, Marhaver KL, Bongaerts P, Latijnhouwers KRW, Vergara-Flórez DC, Snowden S, Sánchez JA, Vermeij MJA.   +8 more
europepmc   +1 more source

Reproductive health; developing partnerships in the study of reproductive hazards in the workplace

"NIOSH conducts 3 types of field studies: Health Hazard Evaluations: initiated by workers or employers and mandated by Congress. Industry-wide studies: initiated by NIOSH and based on scientific data.

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