Results 191 to 200 of about 1,448,748 (289)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Does Asymmetric Reproductive Isolation Predict the Direction of Introgression in Plants? [PDF]

Genes (Basel)
Martin NH, Zalmat AS, Ellis BS, McGarvey S, Simmons-Frazier K, Mancusi K, Sotola VA.   +6 more
europepmc   +1 more source

Epigenetics and reproductive isolation: a commentary on Westram et al., 2022. [PDF]

J Evol Biol, 2022
Planidin NP, de Carvalho CF, Feder JL, Gompert Z, Nosil P.   +4 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Reproductive isolation in two strains of the marine rotifer <i>Brachionus</i> cf. <i>ibericus</i> (Rotifera, Monogononta) from Quintana Roo, México. [PDF]

Biodivers Data J
Marin-Chan AG, Pérez-Yáñez D, Acosta-González G, Alvarado-Flores J.   +3 more
europepmc   +1 more source

Morphological variation and reproductive isolation in the Hetaerina americana species complex. [PDF]

Sci Rep, 2022
Vega-Sánchez YM, Mendoza-Cuenca L, González-Rodríguez A.   +2 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Ecological niche differentiation mediates near complete premating reproductive isolation within the Gladiolus carneus (Iridaceae) species complex. [PDF]

Ann Bot
Khoury KL, Edwards S, Newman E.
europepmc   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Whole genome sequencing analysis reveals strong reproductive isolation between two hybridizing Rhododendron species in subgenus <i>Tsutsusi</i>. [PDF]

Plant Divers
Tian X, Zhang N, Li X, Zhang Z, Shu H, Zhang C, Ma Y, Geng Y.   +7 more
europepmc   +1 more source