Results 91 to 100 of about 386,943 (302)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

The State of Reproductive Health and Rights: 50 State Report Card [PDF]

open access: yes, 2014
The status of reproductive health and rights in the U.S. is at an historic crossroads. At the federal level, the Affordable Care Act is expanding insurance coverage for reproductive health services, but at the state level political assaults on Planned ...

core  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Reproductive Health and the Millennium Development Goals I: The Missing Link [PDF]

open access: yes, 2004
When the General Assembly adopted the Millennium Declaration in 2000 and, a year later, the Millennium Development Goals, an explicit commitment to the reproductive rights of women was nowhere to be ...
Barbara Crossette
core  

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

The association between reproductive rights and access to abortion services and mental health among US women. [PDF]

open access: yesSSM Popul Health, 2023
Liu SY   +5 more
europepmc   +1 more source

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